Anatomy and Physiology: The Digestive System to accompany

Overview 1 Gastrointestinal (GI) Tract 2 Accessory Organs of the Head 3 Swallowing 4 Stomach 5 Accessory Organs of the Abdomen 6 Small Intestine 7 Large Intestine 8 Phases of Digestion 9 Food Molecules

Essential Terms digestion process of mechanically or chemically breaking down food absorption passage of small molecules into blood and lymph digestive system organs which carry out process of digestion and absorption metabolism all the chemical reactions of the body

Introduction Digestive System Composed of GI tract and accessory organs Breaks down ingested food for use by the body Digestion occurs by mechanical and chemical mechanisms Excretes waste products or feces through process of defecation

GI Tract / Alimentary Canal Continuous tube from mouth to anus Mouth Pharynx Esophagus Stomach Small intestine Large intestine

Accessory Digestive Organs Provide mechanical and chemical mechanisms to aid digestion Teeth Tongue Salivary glands Liver Gallbladder Pancreas

Functions of Digestive System Ingestion Secretion Mixing and propulsion Motility Digestion Mechanical and chemical Absorption Defecation

Layers of GI Tract Same in all areas of GI tract From deep to superficial: Mucosa Submucosa Muscularis Serosa

Figure 23.2

Layers of GI Tract Mucosa Submucosa Epithelium Type varies Lamina propria – areolar connective tissue MALT – mucus-associated lymphatic tissue Muscularis mucosae – smooth muscle Submucosa Areolar connective tissue Blood and lymphatic vessels Neurons – submucosal plexus

Layers of GI Tract Muscularis Serosa Skeletal and smooth muscle Neurons – myenteric plexus Serosa Areolar and simple squamous epithelium Visceral peritoneum

Peritoneum Mesothelium Parietal peritoneum Visceral peritoneum Peritoneal cavity Retroperitoneal

Figure 23.3a

Figure 23.3b

Figure 23.3c

Figure 23.3d

Neural Innervation of GI Tract Regulated by autonomic nervous system Enteric division Myenteric plexus / plexus of Auerbach Submucosal plexus / plexus of Meissner Able to function independently from rest of nervous system Linked to CNS by extrinsic sympathetic and parasympathetic nerves Sympathetic nerves decrease GI secretions & motility Parasympathetic nerves increase GI secretion and motility

Mouth Parts of Digestive System Mouth formed by several parts: Cheeks Lips / labia Labial frenulum Orbicularis Vestibule Oral cavity proper Fauces Hard and soft palate Uvula Palatoglossal and palatopharyngeal arch

Figure 23.4

Tongue Skeletal muscle and mucous membrane Helps form floor of oral cavity Extrinsic muscles Intrinsic muscles Lingual frenulum Papillae Fungiform Filiform Circumvallate Foliate Lingual glands Lingual lipase

Salivary Glands Release saliva to oral cavity 3 pairs of salivary glands Parotid Submandibular Sublingual

Composition of Saliva 99.5 % water 0.5% other solutes Ions Mucus Immunoglobulin A Enzymes Salivation controlled by autonomic nervous system Stimulated by various mechanisms

Figure 23.5

Teeth External regions Internal components Crown Root Neck Enamel Dentin Cementum Pulp cavity PulpRoot canals Apical foramen

Figure 23.6

Teeth Dentitions Deciduous teeth – first set Permanent teeth – secondary Carry out mechanical digestion by mastication Creates bolus Salivary amylase Breakdown starch Lingual lipase Breakdown triglycerides

Figure 23.7

Pharynx Composed of skeletal muscle Lined by mucous membrane Nasopharynx Oropharynx Laryngopharynx

Esophagus Collapsible muscular tube through esophageal hiatus of diaphragm Mucosa Submucosa contains areolar connective tissue Muscularis Skeletal muscle Upper and lower esophageal sphincter Adventitia Attaches esophagus to nearby structures Secrets mucus and transports food

Figure 23.8

Deglutition Stages of swallowing Voluntary Pharyngeal Esophageal Mouth to oropharynx Pharyngeal Deglutition center in medulla oblongata and pons Closing of epiglottis Involuntary Esophageal Peristaltic contractions

Figure 23.9a,b

Figure 23.9c

Table 23.2

Stomach Serves as mixing chamber and storage area for ingested food Rugae allow for increased volume 4 main regions Cardia Fundus Body Pylorus Pyloric antrum and canal Pyloric sphincter Lesser and greater curvatures

Figure 23.10a

Stomach Histology Mucosa Submucosa – areolar connective tissue Surface mucous cells Lamina propria Muscularis mucosae Gastric glands and pits Parietal cells Chief cells G cells Submucosa – areolar connective tissue Muscularis 3 layers of smooth muscle Serosa

Figure 23.11a

Figure 23.11b

Mechanical and Chemical Digestion Mixing waves caused by peristaltic movement Chyme released in process of gastric emptying Proton pumps bring H+ into the lumen Carbonic anhydrase forms carbonic acid to provide H+ and bicarbonate ions (HCO3-)

Figure 23.12

Mechanical and Chemical Digestion Chemical digestion stimulated by nervous system Parasympathetic neurons release acetylcholine Works with gastrin HCl released in presence of histamine Pepsin begins digestion of proteins Stomach protected by alkaline mucus secretion Gastric lipase digests triglycerides Few molecules absorbed by stomach Water, ions, short-chain fatty acids, alcohol

Table 23.3 pt 1

Table 23.3 pt 2

Pancreas Produces secretions to aid digestion Head Body Tail Pancreatic duct /duct of Wirsung Hepatopancreatic ampulla Sphincter of the heatopancreatic ampulla (sphincter of (Oddi) Regulates passage of pancreatic juice and bile Accessory duct (duct of Santorini)

Figure 23.13a

Figure 23.13b

Figure 23.13c

Histology of Pancreas Glandular epithelial cells 99% exocrine clusters Secrete pancreatic juice Fluid and enzymes Pancreatic islets (islets of Langerhans) 1% endocrine cells Hormones Glucagon Insulin Somatostatin Pancreatic polypeptide

Pancreatic Juice 1200-1500 mL/day pH 7.1-8.2 Water Salts Sodium bicarbonate Enzymes Pancreatic amylase Trypsin Entereokinase Chymotrypsin Carboxypeptidase Elastase Pancreatic lipase Ribonuclease and deoxyribonuclease

Liver and Gallbladder Liver Largest gland at 1.4 kg (~3 lb) Closely associated with liver

Anatomy of Liver Right and left lobe separated by falciform ligament Quadrate lobe Caudate lobe Round ligament (ligamentum teres) Remnant of umbilical vein coronary ligaments

Histology of Liver Lobule Reticuloendothelial (Kupffer) cells Hepatocytes radiating from central vein Sinusoids Reticuloendothelial (Kupffer) cells Stationary phagocytes

Figure 23.14a

Figure 23.14b

Figure 23.14c

Figure 23.14d

Bile Duct System Bile secreted by hepatocytes Bile canaliculi Right and left hepatic ducts Common hepatic duct Common bile duct Gallbladder for temporary storage of bile Cystic duct

Blood Supply of Liver Hepatic artery provides oxygenated blood Hepatic portal vein provides deoxygenated blood Nutrients, drugs, toxins, microbes Hepatic artery and vein carry blood to sinusoids Substances exchanged by hepatocytes Blood drains to central vein and eventually hepatic vein Portal triad Hepatic portal vein Hepatic artery Bile duct

Figure 23.15

Bile 800-1000 mL/day pH 7.6 – 8.6 Water Bile acids Bile salts Emulsification Cholesterol Lecithin Bile pigments Bilirubin Stercobilin

Liver Functions Metabolism of: Process drugs and hormones Carbohydrates Lipids Proteins Process drugs and hormones Excrete bilirubin Synthesize bile salts Storage Glycogen Vtamins Minerals Phagocytosis Activate Vitamin D

Small Intestine Adapted for digestion and absorption 3 m (10 ft) living 6.5 m (21 ft) without muscle tone Duodenum Jejunum Ileum Ileocecal sphincter Connection to large intestine

Figure 23.16a

Figure 23.16b

Histology of Small Intestine Mucosa Cell types Absorptive Goblet Endocrine Paneth Lysozyme Intestinal glands (crypts of Lieberkühn) S cells Hormone secretin CCK cells Hormone – cholecystokinin (CCK)

Figure 23.17a

Figure 23.17b

Histology of Small Intestine MALT – mucosa-associated lymphoid tissue Solitary lymphatic nodules Aggregated lymphatic follicles (Peyer’s patches) Submucosa Duodenal (Brunner’s glands) Alkaline secretion Muscularis Serosa

Adaptive Structures Small Intestine Circular folds / plicae circulares Villi Lacteal Lymphatic capillary Microvilli Brush border Brush border enzymes Intestinal juice 1-2 liters / day pH 7.6

Figure 23.18a

Figure 23.18b

Mechanical Digestion in Small Intestine Segmentation Localized Mix chyme with digestive juices Important for process of absorption Peristalsis Movement along the length of small intestine

Chemical Digestion in Small Intestine Completes digestion of food from the stomach Carbohydrates Pancreatic amylase Glycogen and starch only -dextrinase Sucrase Lactase Maltase

Chemical Digestion in Small Intestine Proteins Trypsin Chymotrypsin Elastase Carboxypeptidase Peptidases

Chemical Digestion in Small Intestine Lipids Pancreatic lipase Emulsification Amphipathic bile salts Nucleic acids Nucleosidases Phosphatases

Table 23.4 pt 1

Table 23.4 pt 2

Absorption in Small Intestine Passage of digested nutrients from gastointestinal tract into blood or lymph 90% of nutrients absorbed through small intestine Monosaccharides Facilitated diffusion Fructose Secondary active transport Glucose Galactose Enter blood through hepatic portal system

Absorption in Small Intestine Amino acids Active transport Na+-dependent secondary active transport Dipeptides and tripeptides Symporter with H+

Absorption in Small Intestine Lipids by simple diffusion Due to emulsification and digestion Micelles formed due to amphipathic nature of bile salts Chylomicrons Triglycerides coated with proteins Leave cells via exocytosis Enter blood vessels via lymphatic system Enterohepatic circulation

Absorption in Small Intestine Electrolytes Diffusion Active transport Secondary active transport Vitamins Water Osmosis

Anatomy of Large Intestine Mesocolon attaches to posterior abdominal wall Regions Cecum Colon Rectum Anal canal Ileocecal sphincter (valve) Allows passage into large intestine

Figure 23.21a

Figure 23.21b

Anatomy of Large Intestine Cecum Pouch Attached appendix / veriform appendix Colon Ascending Transverse Descending Sigmoid Right and Left colic (splenic) flexures Rectum Anal canal Anal columns Anus Internal and external sphincter

Histology of Large Intestine Mucosa Absorptive cells absorb mainly water Goblet cells secrete mucus Lymphatic nodules Submucosa Muscularis Haustra External longitudinal smooth muscle Teniae coli Internal circular smooth muscle Serosa Epiploic appendages

Figure 23.22a

Figure 23.22b

Figure 23.22c

Figure 23.22d

Mechanical digestion in Large Intestine Gastroileal reflex Intensifies after a meal Occurs 3 or 4 times a day Haustral churning Distension and contraction of haustra Peristalsis Mass peristalsis

Chemical Digestion in Large Intestine Bacteria: Ferment carbohydrates Gases produced are flatus or flatulence when excessive Break down proteins Decompose bilirubin Feces formed of dried chyme, inorganic salts, mucus, bacteria, undigested foods and other substances

Defecation Reflex Empties the rectum Response to distention of rectal wall External anal sphincter voluntarily relaxed defecation occurs

Table 23.7

Phases of Digestion Cephalic Gastric Intestinal Cephalic Phase Stimulation of the senses activates CNS Prepares mouth and stomach for food

Phases of Digestion Gastric Phase Begins with food in the stomach Neural regulation Negative feedback system Stretch receptors Chemoreceptors Hormonal regulation Gastrin Released by G cells of gastric glands Controlled by negative feedback mechanism (pH)

Phases of Digestion Intestinal Phase Neural regulation Begins with food in the small intestine Inhibitory effects to slow exit of chyme Neural regulation Enterogastric reflex Distension of duodenum

Phases of Digestion Intestinal Phase continued Hormonal regulation Cholecystokinin (CCK) Stimulates release of pancreatic juice Contraction of gallbladder wall Relaxes sphincter of hepatopancreatic ampulla Secretin Response to acidic chyme Stimulates flow of pancreatic juice for buffering Inhibits secretion of gastric juice

Table 23.8

Six Main Types of Nutrients Water Carbohydrates Lipids Proteins Minerals Vitamins Essential nutrients cannot be made in sufficient amounts by the body

Guidelines for Healthy Eating Variety Maintain healthy weight Choose low fat foods Lots of vegetables, fruits, and grains Sugar in moderation Salt and sodium in moderation Alcohol in moderation Food Guide Pyramid

Figure 23.24

Nutrients Inorganic elements constitute 4% of body mass Minerals Inorganic elements constitute 4% of body mass Regulate enzymatic reactions Serve as coenzymes Vitamins Organic molecules required in small amounts Most function as coenzymes Most cannot be synthesized by body Provitamins Fat-soluble vitamins A, D, E, and K Water soluble vitamins B and C Antioxidant vitamins

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