Transcriptional control: Imprinting insulation

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Transcriptional control: Imprinting insulation Alan P. Wolffe Current Biology Volume 10, Issue 12, Pages R463-R465 (June 2000) DOI: 10.1016/S0960-9822(00)00534-0

Figure 1 Regulated insulator activity in the Igf2–H19 locus. (a) The Igf2 and H19 genes are indicated on the 90 kb locus, with the hooked arrows indicating the start site and direction of transcription of each gene. The relative positions of the insulator (at the imprinting control region) and the enhancer are shown. (b) In the maternal unmethylated locus, CTCF can bind to the insulator and prevent the 3′ enhancer from activating the Igf2 promoter. The enhancer can still efficiently activate the unmethylated H19 promoter. (c) In the paternal methylated locus, CTCF can no longer bind to the insulator because the DNA is methylated (indicated by ‘Me’) and insulator activity is lost. In addition, methylation of the H19 gene sequence represses transcription directly. Now enhancer activity is focussed on activation of the Igf2 promoter. Current Biology 2000 10, R463-R465DOI: (10.1016/S0960-9822(00)00534-0)