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Evidence for genetic heterogeneity in Dent's disease

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Presentation on theme: "Evidence for genetic heterogeneity in Dent's disease"— Presentation transcript:

1 Evidence for genetic heterogeneity in Dent's disease
Richard R. Hoopes, Khalid M. Raja, April Koich, Paul Hueber, Robert Reid, Stephen J. Knohl, Steven J. Scheinman  Kidney International  Volume 65, Issue 5, Pages (May 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions

2 Figure 1 CLCN5 gene promoter region. Major promoter activity maps to the 5′ region of exon la, while a weaker promoter maps to the 5′ region of exon lb (bold arrows). Possible regulatory protein binding regions are labeled, 5′ of the transcription start sites. Double arrows indicate regions of the promoters that were sequenced (not to scale) [36]. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions


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