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A KRABsody for Embryo-Placental Development

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Presentation on theme: "A KRABsody for Embryo-Placental Development"— Presentation transcript:

1 A KRABsody for Embryo-Placental Development
Didier Trono  Developmental Cell  Volume 41, Issue 6, Pages (June 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 The Igf2-Controlling KRAB-ZFP Duet in Murine ESCs
In the wild-type cellular context, at the maternal allele, CTCF is recruited to the unmethylated Igf2/H19 ICR and blocks Igf2 promoter activation by distal enhancer. At the paternal allele, ZFP57 is recruited at the methylated Igf2/H19 ICR, allowing activation of Igf2 promoters. However, P0 is silenced and P1–P3 are dampened by ZFP568-induced repression. In ZFP568 KO embryonic stem cells (ESCs) at the paternal allele, the P0 promoter is unleashed and P1–P3 are further activated, resulting in increased IGF2 levels. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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