1. Alignment of distal NOS2 promoters from cattle, human, and sheep, and the Bov-A2 element.
Alignment of distal NOS2 promoters from cattle, human, and sheep, and the Bov-A2 element. NOS2 promoter sequences were obtained from Ensembl. (A and B) show pairwise dot-matrix alignment of 25 kb sequences upstream of NOS2 transcription start site from (A) cattle (y-axis) versus human (x-axis), and (B) sheep (y-axis) versus cattle (x-axis). The arrow in (A) indicates the relative location of the mouse Nos2 enhancer. In (B), small insertions showing misalignment are indicated by arrows. (C and D) show the alignment of the Bov-A2 element with the cattle (C) and sheep (D) 25 kb NOS2 promoter regions. Arrows indicate regions occupied by partial or complete Bov-A2 elements.
Rachel Young et al. ImmunoHorizons 2018;2:27-37
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