1. Volume 28, Issue 6, Pages 725-727 (June 2008)
Permission to Proceed: Jak3 and STAT5 Signaling Molecules Give the Green Light for T Helper 1 Cell Differentiation 
Kenneth M. Murphy 
Immunity 
Volume 28, Issue 6, Pages (June 2008)
DOI: /j.immuni
Copyright © 2008 Elsevier Inc. Terms and Conditions

2. Figure 1 Action of Jak3 and STAT5 in Th1 Cell Development
As shown in the left panel, the conserved noncoding sequence (CNS)-22, located 22 kb upstream of the interferon-γ (Ifng) gene promoter binds T-bet, shows an active chromatin configuration even in naive CD4+ T cells, and may represent the initial platform of activation. Shi et al. (2008) show that in the absence of Jak3, T-bet is unable to gain access to sites more proximal to the Ifng promoter. The right panel shows that upon IL-2 signaling, STAT5 itself binds to CNS1 (at −5 kb) and to sites near the promoter, suggesting a model in which IL-2, Jak3, and STAT5 form a system to permit encroachment of T-bet into the Ifng locus.
Immunity  , DOI: ( /j.immuni )
Copyright © 2008 Elsevier Inc. Terms and Conditions