T-bethi MP cells produce IFN-γ in response to IL-12.

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T-bethi MP cells produce IFN-γ in response to IL-12. T-bethi MP cells produce IFN-γ in response to IL-12. (A) IL-12p70 induces IFN-γ production by MP cells. IFN-γ–eYFP reporter mice were treated intraperitoneally with IFN-γ, IL-12p70, or IL-18 on days 0 and 1, and on day 2, MP cells were analyzed for IFN-γ expression in the PC and spleen. The representative histograms indicate the frequency of IFN-γ+ cells among MP cells, and the bar graph shows the frequency (mean ± SD) of IFN-γ+ cells (n = 4). Data are pooled from two independent experiments. (B) Neutralization of IL-12 abolishes IFN-γ production by MP cells during T. gondii infection. IFN-γ–eYFP reporter mice infected with T. gondii were treated with blocking anti–IL-12 mAb or control IgG, and MP cells in the PC and spleen were analyzed for IFN-γ expression on day 2. The numbers in the histograms show the frequency of IFN-γ+ cells among MP cells, and the graphs indicate the number (mean ± SD) of IFN-γ+ MP cells from each group (n = 3 to 6). Data are pooled from two independent experiments. (C) T-bethi but not T-betlo MP cells produce IFN-γ in response to IL-12p70. IFN-γ–eYFP T-bet–AmCyan double reporter mice were treated with IL-12p70, as described in (A), and MP cells from the PC and spleen were analyzed for IFN-γ–eYFP and T-bet–AmCyan expression. The representative histograms indicate the frequency of IFN-γ+ cells among T-bethi and T-betlo MP cells, and the bar graphs show the frequency (mean ± SD) of IFN-γ+ cells among each MP subset (n = 3 to 5). Data are pooled from two independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001. Takeshi Kawabe et al. Sci. Immunol. 2017;2:eaam9304 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.