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Fig. 5 Impaired colitis induction by LRH-1–deficient CD4+T cells.

Published byΠέρσις Κοτζιάς Modified over 4 years ago

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Presentation on theme: "Fig. 5 Impaired colitis induction by LRH-1–deficient CD4+T cells."— Presentation transcript:

1 Fig. 5 Impaired colitis induction by LRH-1–deficient CD4+T cells.
Impaired colitis induction by LRH-1–deficient CD4+T cells. (A) Scheme of transfer colitis induction in Rag1−/− recipient mice. (B) Colitis-induced loss of body weight (L2/L2 donor, n = 14; cKO donor, n = 9). (C to E) Representative histologies of colon samples from untreated Rag1−/− recipient mice (C) or after transfer of naïve L2/L2 (D) or cKO T cells (E). Top panels: Lower magnification. Bottom panels: Higher magnification. Scale bars, 150 μm. (F and G) Repopulation of spleen (F) or mesenteric lymph node (mLN) (G) by naïve L2/L2 or cKO T cells. (H to J) mRNA expression levels of the proinflammatory cytokines tumor necrosis factor–α (H), IL-1β (I), and IFN-γ (J) in colon samples or control recipients or recipients transferred with L2/L2 or cKO T cells. Mean ± SD and individual data points of n = 9 to 14 mice are shown. *P < 0.05, **P < 0.01, and ***P < Carina Seitz et al. Sci Adv 2019;5:eaav9732 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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