1. β-Glucans do not modulate epithelial IL-33 or AHR.
β-Glucans do not modulate epithelial IL-33 or AHR. (A) Supernatant IL-33 levels measured from 16HBE cells exposed to media or HDM, which was preincubated with PBS, vehicle, or β-glucanase. (B) AHR in A/J mice receiving PBS, HDM, β-glucanase–treated HDM, or HDM exposed to control conditions (veh + 56°C; see Materials and Methods). AHR in C57BL/6 mice exposed to either (C) PBS, HDM, or HDM + curdlan or (D) PBS, OVA, or OVA + curdlan (details in Materials and Methods). Data are means + SEM pooled from two independent experiment (A) or are representative of two independent experiments (B to D) with n = 3 to 8 mice per group. ****P < , as determined by one-way ANOVA followed by post hoc analysis.
Naina Gour et al. Sci. Immunol. 2018;3:eaam9841
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