1. Tfr cell–derived IL-10 is important for B cell differentiation and the GC response.
Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. (A) Analysis of the B cell response at day 15 after acute LCMV Armstrong infection in 50:50 Il10f/f/Bcl6f/fFoxp3-Cre or Il10f/fFoxp3-Cre/Bcl6f/fFoxp3-Cre mBMCs. Left: Schematic for the experiment. Right: Data are pooled from two experiments with four to five mice per group carried out 15 days after LCMV Armstrong infection. (B) Analysis of the B cell response at day 15 after acute LCMV Armstrong infection in 50:50 Il10f/f/SAP−/− or Il10f/fFoxp3-Cre/SAP−/− mBMCs. Left: Schematic for the experiment. Right: Data are from one experiment representative of two experiments with four to nine mice per group carried out 15 days after LCMV Armstrong infection. Statistical analyses were performed using unpaired two-tailed Student’s t test (*P < 0.05; **P < 0.01; ***P < 0.001).
Brian J. Laidlaw et al. Sci. Immunol. 2017;2:eaan4767
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