Possible sites of action of aspirin in the prevention of colorectal cancer. Possible sites of action of aspirin in the prevention of colorectal cancer.

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Possible sites of action of aspirin in the prevention of colorectal cancer. Possible sites of action of aspirin in the prevention of colorectal cancer. COX-dependent and independent targets of aspirin are likely to be present in both epithelial and stromal cell compartments in colorectal adenomas and cancers. ATLs, aspirin-triggered lipoxins; COX, cyclooxygenase; PGE2, prostaglandin E2; S-1P, sphingosine-1-phosphate. Andrew T. Chan et al. Cancer Prev Res 2012;5:164-178 ©2012 by American Association for Cancer Research