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Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by.

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Presentation on theme: "Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by."— Presentation transcript:

1 Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by Sanjiv Dhingra, Peng Li, Xi-Ping Huang, Jian Guo, Jun Wu, Anton Mihic, Shu- Hong Li, Wang-Fu Zang, Daniel Shen, Richard D. Weisel, Pawan K. Singal, and Ren-Ke Li Circulation Volume 128(11 suppl 1):S69-S78 September 10, 2013 Copyright © American Heart Association, Inc. All rights reserved.

2 Differentiation of mesenchymal stem cells (MSCs) decreased prostaglandin E2 (PGE2), cyclooxygenase 2 (COX2), and prostaglandin E synthase-1 (PTGES1) levels. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

3 Prostaglandin E2 (PGE2) decrease in differentiated mesenchymal stem cells (D-MSCs) was associated with the loss of immunoprivilege. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

4 Prostaglandin E2 (PGE2) decrease in differentiated mesenchymal stem cells (D-MSCs) was associated with loss of T regulatory (Treg) cell induction. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

5 Prostaglandin E2 (PGE2) maintained mesenchymal stem cell (MSC) chemotactic ability. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

6 Chemokines maintained mesenchymal stem cell (MSC) immunoprivilege. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

7 Prostaglandin E2 (PGE2) increased survival of transplanted mesenchymal stem cells (MSCs) in the heart and alleviated the host immune response. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

8 In vivo differentiation of transplanted mesenchymal stem cells (MSCs). Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

9 Maintaining prostaglandin E2 (PGE2) levels in transplanted mesenchymal stem cells (MSCs) preserved heart function. Sanjiv Dhingra et al. Circulation. 2013;128:S69-S78 Copyright © American Heart Association, Inc. All rights reserved.

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