Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: Duminda N Wijeysundera, MD, Jennifer S Naik, MD, W Scott Beattie, MD,

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Presentation transcript:

Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: Duminda N Wijeysundera, MD, Jennifer S Naik, MD, W Scott Beattie, MD, PhD The American Journal of Medicine Volume 114, Issue 9, Pages 742-752 (June 2003) DOI: 10.1016/S0002-9343(03)00165-7

Figure 1 Flow diagram of meta-analysis. The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)

Figure 2 Effect of α2-agonists on mortality during all types of surgery, with a combined analysis of these results. Squares represent point estimates. The area of a square correlates with its contribution towards the weighted summary estimate. Horizontal lines denote 95% confidence intervals (CI), some of which extend beyond the limits of the scale. The overall effect, represented by the diamond, was a relative risk of 0.64 (95% CI: 0.42 to 0.99; P for heterogeneity = 0.92). The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)

Figure 3 Effect of α2-agonists on myocardial infarction during all types of surgery, with a combined analysis of these results. Squares represent point estimates. The area of a square correlates with its contribution towards the weighted summary estimate. Horizontal lines denote 95% confidence intervals (CI), some of which extend beyond the limits of the scale. The overall effect, represented by the diamond, was a relative risk of 0.85 (95% CI: 0.65 to 1.11; P for heterogeneity = 0.55). The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)

Figure 4 Effect of α2-agonists on myocardial ischemia during all types of surgery, with a combined analysis of these results. Squares represent point estimates. The area of a square correlates with its contribution towards the weighted summary estimate. Horizontal lines denote 95% confidence intervals (CI), some of which extend beyond the limits of the scale. The overall effect, represented by the diamond, was a relative risk of 0.76 (95% CI: 0.63 to 0.91; P for heterogeneity = 0.59). The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)

Figure 5 Effect of α2-agonists on mortality during vascular surgery, with a combined analysis of these results. Squares represent point estimates. The area of a square correlates with its contribution towards the weighted summary estimate. Horizontal lines denote 95% confidence intervals (CI), some of which extend beyond the limits of the scale. The overall effect, represented by the diamond, was a relative risk of 0.47 (95% CI: 0.25 to 0.90; P for heterogeneity = 0.82). The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)

Figure 6 Effect of α2-agonists on myocardial infarction during vascular surgery, with a combined analysis of these results. Squares represent point estimates. The area of a square correlates with its contribution towards the weighted summary estimate. Horizontal lines denote 95% confidence intervals (CI), some of which extend beyond the limits of the scale. The overall effect, represented by the diamond, was a relative risk of 0.66 (95% CI: 0.46 to 0.94; P for heterogeneity = 0.21). The American Journal of Medicine 2003 114, 742-752DOI: (10.1016/S0002-9343(03)00165-7)