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Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms  Robert M. Kwee, MD  Journal of Vascular.

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Presentation on theme: "Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms  Robert M. Kwee, MD  Journal of Vascular."— Presentation transcript:

1 Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms  Robert M. Kwee, MD  Journal of Vascular Surgery  Volume 51, Issue 4, Pages (April 2010) DOI: /j.jvs Copyright © 2010 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Forest plot of the association between plaque calcification volume or weight and clinical ischemic symptoms; study-specific and pooled standardized mean differences (SMDs) for studies using a rating scale or continuous measure of calcification volume or weight. Bullets represent each individual study's SMD estimate. At the bottom of the plot, bullets represent the pooled estimate, both for the fixed and random-effects models. The lines extending from the bullets represent the 95% confidence interval (CI) for the estimates. A vertical line through the referent (0.0) has also been plotted. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Forest plot of the association between plaque calcification percentage and clinical ischemic symptoms; study-specific and pooled standardized mean differences (SMDs) for studies using a rating scale or continuous measure of calcification percentage. Bullets represent each individual study's SMD estimate. At the bottom of the plot, bullets represent the pooled estimate, both for the fixed and random-effects models. The lines extending from the bullets represent the 95% confidence interval (CI) for the estimates. A vertical line through the referent (0.0) has also been plotted. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Forest plot of the association between degree of plaque calcification and plaque clinical ischemic symptoms; study-specific and pooled odds ratios (ORs) for studies using a dichotomous measure of degree of plaque calcification. Bullets represent each individual study's standardized mean difference (SMD) estimate. At the bottom of the plot, bullets represent the pooled estimate, both for the fixed and random-effects models. The lines extending from the bullets represent the 95% confidence interval (CI) for the estimates. A vertical line through the referent (1.0) has also been plotted. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

5 Fig 4 A, Funnel plots on studies using calcification volume or weight, (B) calcification percentage, (C) and dichotomous calcification measure. The vertical axis is a measure of the precision of the effect size of a study, in this case represented by the SE of the standardized mean difference (SMD) or log odds ratio (OR) (the log OR was used, because it can take any value and has an approximately normal distribution). The horizontal axis measures the study's effect size, in this case, the SMD or log OR. The point estimate from each study has been plotted, and a vertical line has been added where the pooled estimate from the meta-analysis lies. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions


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