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Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis  Wendy T. Chen, PharmD, Guru M. Krishnan,

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Presentation on theme: "Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis  Wendy T. Chen, PharmD, Guru M. Krishnan,"— Presentation transcript:

1 Effect of statins on atrial fibrillation after cardiac surgery: A duration- and dose-response meta-analysis  Wendy T. Chen, PharmD, Guru M. Krishnan, MD, Nitesh Sood, MD, Jeffrey Kluger, MD, Craig I. Coleman, PharmD  The Journal of Thoracic and Cardiovascular Surgery  Volume 140, Issue 2, Pages (August 2010) DOI: /j.jtcvs Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart. RCT, Randomized, controlled trial; CTS, cardiothoracic surgery. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Statins' effects on postoperative atrial fibrillation (A), intensive care unit stay (B), and total hospital stay (C). All pooled results were calculated with DerSimonian and Laird random-effects model. RR, Relative risk; CI, confidence interval; WMD, weighted mean difference. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Risk ratio (RR) of postoperative atrial fibrillation associated with duration of preoperative statin use. Greater weight of study corresponds to larger area of circle and to greater contribution of study to overall pooled effect. Superimposed line was obtained by conducting random-effects metaregression analysis with restricted maximum likelihood method to estimate residual variance resulting from heterogeneity. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions


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