Fiona C. Lewis et al. BTS 2017;j.jacbts

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Fiona C. Lewis et al. BTS 2017;j.jacbts.2017.08.002 Transplantation of GFPpos Allogeneic pPICs Accelerates Skeletal Muscle Regeneration (A) HVG staining of uninjured CTRL, CTX-PBS– and CTX-pPIC–treated muscle showing improved skeletal muscle architecture in pPIC-treated muscle, scale bar = 100 μm. Inset shows ×40 magnification, scale bar = 50 μm. (B) Immunohistochemical staining indicates an increase in BrdUpos centralized nuclei in CTX-pPIC–treated muscle compared with uninjured CTRL and CTX-PBS–treated muscle, scale bar 50 = μm. (C) Quantification of the ratio of skeletal muscle to connective tissue CSA in uninjured CTRL, CTX-PBS–, and CTX-pPIC–treated muscle determined from 5 fields of view per muscle, n = 5 animals per group. Data are mean ± SD, *p < 0.01 versus uninjured CTRL, **p < 0.001 versus CTX-pPIC–treated muscle. (D) BrdUpos centralized nuclei per total myofibers, determined from 5 fields of view per muscle, n = 5 animals per group. Data are mean ± SD, *p < 0.0001 versus uninjured CTRL, **p = 0.0012 versus CTX-PBS–treated. (E) Average myofiber diameter of regenerating (BrdUpos centralized nuclei) myofibers determined from 5 fields of view per muscle, n = 5 animals per group. Data are mean ± SD, *p < 0.0001 versus CTX-PBS–treated. CSA = cross sectional area; CTRL = control; CTX = cardiotoxin; HVG = hematoxylin and van Gieson; PBS = phosphate buffered saline; pPIC = porcine PW1pos/Pax7neg interstitial cell. Fiona C. Lewis et al. BTS 2017;j.jacbts.2017.08.002 2017 The Authors