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Figure 1 Muscle biopsy from a patient with a slowly progressive (24 years) HMGCR antibody–associated myopathy syndrome (A) Hematoxylin & eosin stain, (B)

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Presentation on theme: "Figure 1 Muscle biopsy from a patient with a slowly progressive (24 years) HMGCR antibody–associated myopathy syndrome (A) Hematoxylin & eosin stain, (B)"— Presentation transcript:

1 Figure 1 Muscle biopsy from a patient with a slowly progressive (24 years) HMGCR antibody–associated myopathy syndrome (A) Hematoxylin & eosin stain, (B) Verhoeff-van Gieson stain. Muscle biopsy from a patient with a slowly progressive (24 years) HMGCR antibody–associated myopathy syndrome (A) Hematoxylin & eosin stain, (B) Verhoeff-van Gieson stain. Muscle fiber size varies from very small to hypertrophied. Some small muscle fibers have mildly basophilic, or darkly stained, cytoplasm (white arrows). A few muscle fibers have internal nuclei. Endomysial connective tissue between muscle fibers is increased. (C) Alkaline phosphatase stains perimysial connective tissue and the cytoplasm of scattered small muscle fibers (white arrow). (D) Acid phosphatase stains scattered cells in the perimysium and cells associated with a necrotic muscle fiber (black arrow). Scale bar = 50 μM for A, B, and D and 100 μM for C. HMGCR = 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Ali Alshehri et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e124 © 2015 American Academy of Neurology

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