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Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.

Published byTodd Townsend Modified over 5 years ago

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Presentation on theme: "Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells."— Presentation transcript:

1 Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden.
Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. (A) Hematoxylin and eosin (H&E) and immunostaining showing the expression of Maraba proteins and cytokeratin-18 in a triple-negative breast cancer (TNBC) patient-derived xenograft (PDX) treated intratumorally with Maraba (n = 2). Scale bars, 200 μm. NV, no virus. (B to D) Quantification of average non-necrotic regions based on H&E staining obtained for the TNBC PDX (B), the luminal B breast cancer PDX (C), or 4T1 tumors (D) (n = 10; Mann-Whitney two-tailed U test, ***P < 0.005). PBS, phosphate-buffered saline. (E and F) Maraba was administered intratumorally to 4T1 tumors before resection, and the spontaneous lung metastases were visualized by histology (E) (n = 6; Mann-Whitney two-tailed U test, **P < 0.01) or India ink perfusion (F) (n = 5 for control and n = 6 for Maraba-treated mice; Mann-Whitney two-tailed U test, *P < 0.05). (G and H) The experiment was repeated in the EMT6 (G; n = 10) and E0771 (H; n = 10) tumor models. Marie-Claude Bourgeois-Daigneault et al., Sci Transl Med 2018;10:eaao1641 Published by AAAS

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