Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD

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A Meta-Analysis of Induction Therapy for Advanced Thymic Epithelial Tumors Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD The Annals of Thoracic Surgery Volume 99, Issue 5, Pages 1848-1856 (May 2015) DOI: 10.1016/j.athoracsur.2014.12.048 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The flow of selecting studies papers following PRISMA (preferred reporting items for systematic reviews and meta-analysis) statement. The Annals of Thoracic Surgery 2015 99, 1848-1856DOI: (10.1016/j.athoracsur.2014.12.048) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Pooled rate of response to induction therapy, (B) pooled rate of complete resection after induction therapy, and (C) pooled odds ratios of the response to complete resection for advanced thymic epithelial tumors. The left portions of the figures show the studies analyzed with their corresponding rates or odds ratio, lower and upper limits, z values, and p values. The right portions of the figures show a forest plot of the data. The squares symbolize the effect size for each study. The larger the square, the more weight it contributes to the results of the meta-analysis. The horizontal lines represent the values within the 95% confidence interval (CI) of the underlying effects. The diamond denotes the weighted mean difference, and the lateral tips of the diamond indicate the associated CIs. (M-H = Mantel-Haenszel test; IV = inverse variance; SE = standard error.) The Annals of Thoracic Surgery 2015 99, 1848-1856DOI: (10.1016/j.athoracsur.2014.12.048) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Pooled 5-year overall survival (OS) rate after induction therapy, (B) pooled 10-year OS rate after induction therapy, (C) pooled 5-year OS rate after surgical resection after induction therapy, and (D) pooled 10-year OS rate after surgical resection after induction therapy. The left portions of the figures show the studies analyzed with their corresponding rates, lower and upper limits, z values, and p values. The right portions of the figures show a forest plot of the data. The squares symbolize the overall survival rate for each study. The larger the square, the more weight it contributes to the results of the meta-analysis. The horizontal lines represent the values within the 95% confidence interval (CI) of the underlying effects. The diamond denotes the weighted mean difference and the lateral tips of the diamond indicate the associated CIs. (IV = inverse variance; SE = standard error.) The Annals of Thoracic Surgery 2015 99, 1848-1856DOI: (10.1016/j.athoracsur.2014.12.048) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Funnel plots of precision by log standard error (SE) show that almost all of the studies fall symmetrically, suggesting a lack of important publication bias, in analyses on (A) the rate of response to induction therapy, (B) the rate of complete resection after induction therapy, (C) the odds ratio (OR) of response to induction therapy and complete resection, (D) 5-year overall survival (OS) after induction therapy, (E) 10-year OS after induction therapy, (F) 5-year OS after surgical resection, and (G) 10-year OS after surgical resection for advanced thymic epithelial tumors. (SMD = standardized mean difference.) The Annals of Thoracic Surgery 2015 99, 1848-1856DOI: (10.1016/j.athoracsur.2014.12.048) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions