Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman.

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Presentation transcript:

Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman S.H. Abd allah, Dalia M. Badary Pathophysiology Volume 24, Issue 1, Pages 39-44 (March 2017) DOI: 10.1016/j.pathophys.2017.02.002 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig 1 Levels of lead in the liver, serum ALT, AST and GGT and hepatic total peroxide and IL-1β in different experimental groups. Data presented as means±SEM (n=6 in each group).a Significantly difference vs the negative control group (p<0.05).b Significantly difference vs the positive control group (p<0.05).c Significantly difference vs the lead-exposed group (p<0.05). Pathophysiology 2017 24, 39-44DOI: (10.1016/j.pathophys.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Hepatic sections stained by haematoxylin and eosin from different experimental groups. Negative control group (A; 200×) and positive control group (B; 400×) show normal architecture of hepatic tissue with normal hepatocytes; Arrows in hepatic sections obtained from lead-exposed rats demonstrate an aggregate of inflammatory cells in the portal triads and hepatocytes (C; 200×); Kupffer cells hyperplasia (D; 200×); anisonucleosis (E; 400×); nuclear vesiculation (F; 400×); hepatocytes binucleation (G; 400×); cytoplasmic eosinophilia in some hepatocytes (H; 200×); hepatocytes hydropic degeneration (I; 400×); Lead-treated group shows a reduction in the periportal and lobular inflammatory cell infiltration and disappearance of cytoplasmic eosinophilia, nuclear vesiculation and hydropic degeneration (J; 200×, K, L; 400×). Pathophysiology 2017 24, 39-44DOI: (10.1016/j.pathophys.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Hepatic sections stained by PAS and immunostained by NF-κB from different experimental groups (400×). Negative control group (A) and positive control group (C) show normal glycogen content; E: lead-exposed rat demonstrating mild glycogen depletion involving many hepatic cells; G: Lead-treated group shows normal content of glycogen particles. An over-expression of NF-κB protein in hepatocytes of lead-exposed rats group (F) in comparison to the negative control (B), the positive control (D) and rats received concurrent treatment with folic acid (H). Pathophysiology 2017 24, 39-44DOI: (10.1016/j.pathophys.2017.02.002) Copyright © 2017 Elsevier B.V. Terms and Conditions