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Volume 25, Issue 2, Pages (June 2018)

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1 Volume 25, Issue 2, Pages 83-88 (June 2018)
Increased glomerular Bax/Bcl2 ratio is positively correlated with glomerular sclerosis in lupus nephritis  Ghada Hosny, Wesam Ismail, Rania Makboul, Fatma A.M. Badary, Thanaa M.M. Sotouhy  Pathophysiology  Volume 25, Issue 2, Pages (June 2018) DOI: /j.pathophys Copyright © 2018 Elsevier B.V. Terms and Conditions

2 Fig 1 Bcl2 immunohistochemical expression. (A): A glomerulus from the normal control kidney tissue showing bcl2 expression in tubules and parietal epithelial cells and no staining within the glomerular tuft (×400). (B and C): Bcl2 immunostaining within mesangial cells in glomeruli of LN (×400). (D): Bcl2 immunostaining in an early crescent in LN (×400). Pathophysiology  , 83-88DOI: ( /j.pathophys ) Copyright © 2018 Elsevier B.V. Terms and Conditions

3 Fig. 2 The mean number of intraglomerular bcl2 positive cells in different classes of LN. Pathophysiology  , 83-88DOI: ( /j.pathophys ) Copyright © 2018 Elsevier B.V. Terms and Conditions

4 Fig. 3 Bax immunohistochemical expression. (A): A glomerulus from the normal control kidney tissue showing bax expression in tubules and no staining within the glomerular tuft (×400). (B): Bax immunostaining within visceral epithelial cells in a glomerulus of LN (×400). (C): Bax immunostaining within mesangial cells in a glomerulus of LN (×400). (D): Bax immunostaining in a crescent in LN (×400). Pathophysiology  , 83-88DOI: ( /j.pathophys ) Copyright © 2018 Elsevier B.V. Terms and Conditions

5 Fig. 4 Correlation between the bax to bcl2 ratio and the degree of glomerular sclerosis. 0 = No glomerular sclerosis. 1 = mild (less than 25% of the glomeruli are sclerosed). 2 = moderate (25–50% of glomeruli are sclerosed). Pathophysiology  , 83-88DOI: ( /j.pathophys ) Copyright © 2018 Elsevier B.V. Terms and Conditions


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