1. Volume 22, Issue 2, Pages 117-123 (June 2015)
Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats 
Alkın Kumral, Murat Giriş, Merva Soluk-Tekkeşin, Vakur Olgaç, Semra Doğru-Abbasoğlu, Ümit Türkoğlu, Müjdat Uysal 
Pathophysiology 
Volume 22, Issue 2, Pages (June 2015)
DOI: /j.pathophys
Copyright © 2015 Elsevier B.V. Terms and Conditions

2. Fig. 1
The effect of olive leaf extract (OLE) treatments at two dosages (500 and 1000mg/kg/day) on doxorubicin (DOX)-induced histopathologic alterations in the heart, liver and kidney tissues (H&E). (a) Control group: normal cardiac muscles, liver and kidney histologies (400×), (b) DOX group: interstitial edema, irregular clusters of myocardial fibers of cardiac muscles (200×); necrotic–necrobiotic changes and cellular swelling in midzonal areas of the liver (400×); congestion and necrotic changes resembling acute tubular necrosis in kidney (400×). (c and d) OLE 500+DOX and OLE1000+DOX groups: interstitial edeme, but not necrobiotic changes in cardiac muscle (200×); regenerative changes and cellular swelling in hepatocytes, scant lymhocytic infiltration in the liver (400×); hydropic degeneration and swelling of tubular epithelium in kidney (400×).
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions