1. IL-10 and TGF-β: Roles in chondroprotective effects of Glucosamine in experimental Osteoarthritis? 
Nermien E. Waly, Abeer Refaiy, Nora M. Aborehab 
Pathophysiology 
Volume 24, Issue 1, Pages (March 2017)
DOI: /j.pathophys
Copyright © 2017 Elsevier B.V. Terms and Conditions

2. Fig 1
Serum level of IL-10 (pg/ml) in the experimental groups. GlcN treatment raised the serum level of IL-10 in the osteoarthritic rats at the end of 2 months of treatment; C=control; OA=osteoarthritis; GlcN 50=glucosamine 50mg/kg; GlcN 100=glucosamine 100mg/kg; V=Voltaren. a=significantly different from control at P<0.0001, b=significantly different from OA at P<0.0001, c=significantly different from GlcN 100 at P<
Pathophysiology  , 45-49DOI: ( /j.pathophys )
Copyright © 2017 Elsevier B.V. Terms and Conditions

3. Fig. 2
Serum level of TGF-β1 (ng/ml) in the experimental groups. Glucosamine treatment reduced serum level of TGF-β1 in the osteoarthritic rats at the end of 2 month treatment; C=control; OA=osteoarthritis; GlcN 50=glucosamine 50mg/kg; GlcN 100=glucosamine 100mg/kg; V=Voltaren. a=significantly different from control at P<0.0001, b=significantly different from OA at P<0.0001, c=significantly different from GlcN 100 at P<
Pathophysiology  , 45-49DOI: ( /j.pathophys )
Copyright © 2017 Elsevier B.V. Terms and Conditions

4. Fig. 3
Histopathological sections of hematoxylin and eosin (H&E) stained rat knee joints of the following study groups: a) Control group showing intact superficial layer, normal population and orientation of chondrocytes. b) OA group with erosion, clefting (thin arrow), chondrocytes degeneration (thick arrow), matrix changes and fibrosis. c) GlcN 50 group showing superficial fibrillation, clustering of chondrocytes (thin arrow) and disorientation of chondron columns, d) GlcN 100 showing superficial fibrillation (thin arrow), no clustering. e) V group showing loss of superficial layer (thin arrow), chondrocytes necrosis (thick arrow) and simple fissures. OA=osteoarthritis, GlcN 50=glucosamine at 50mg/kg, GlcN 100=glucosamine at 100mg/kg, V=Voltaren at 30mg/kg. Magnification 400, scale bars 25μm.
Pathophysiology  , 45-49DOI: ( /j.pathophys )
Copyright © 2017 Elsevier B.V. Terms and Conditions