Volume 93, Issue 1, Pages 252-259 (January 2018) Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease  Casey M. Rebholz, Elizabeth Selvin, Menglu Liang, Christie M. Ballantyne, Ron C. Hoogeveen, David Aguilar, John W. McEvoy, Morgan E. Grams, Josef Coresh  Kidney International  Volume 93, Issue 1, Pages 252-259 (January 2018) DOI: 10.1016/j.kint.2017.06.028 Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 1 Spline of adjusted* hazard ratios (95% confidence interval) for incident chronic kidney disease according to baseline plasma level of galectin-3. Histogram of baseline plasma levels of galectin-3 are shown in gray. The solid lines represent the restricted cubic spline with knots at the 5th, 27.5th, 50th, 72.5th, and 95th percentiles for galectin-3. Galectin-3 levels were truncated at the 99th percentile. The 10th percentile of galectin-3 (10.2 ng/ml) was used as the reference point. Dashed lines represent the 95% confidence intervals. *Adjusted for age, sex, race-center, body mass index, smoking, education, physical activity, systolic blood pressure, antihypertensive medication use, history of cardiovascular disease, diabetes, fasting glucose, rs4644, estimated glomerular filtration rate-creatinine, urine albumin-to-creatinine ratio, troponin T, and N-terminal pro B-type natriuretic peptide. Kidney International 2018 93, 252-259DOI: (10.1016/j.kint.2017.06.028) Copyright © 2017 International Society of Nephrology Terms and Conditions