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Volume 61, Issue 1, Pages (January 2002)

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Presentation on theme: "Volume 61, Issue 1, Pages (January 2002)"— Presentation transcript:

1 Volume 61, Issue 1, Pages 96-104 (January 2002)
Protective effects of a soy diet in preventing obesity-linked renal disease  David A. Maddox, Ph.D., Fred K. Alavi, Elizabeth M. Silbernick, Edward T. Zawada  Kidney International  Volume 61, Issue 1, Pages (January 2002) DOI: /j x Copyright © 2002 International Society of Nephrology Terms and Conditions

2 Figure 1 Food consumption (A) and body weights (B) are plotted as a function of age. Values shown are mean ± SEM. Symbols are: (•) casein protein diet; (○) soy protein diet. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

3 Figure 2 Systolic blood pressure (A) and sodium excretion (B) as a function of age. Values shown are mean ± SEM. Symbols are: (•) casein protein diet; (○) soy protein diet. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

4 Figure 3 Glomerular filtration rate (GFR; creatinine clearance) as a function of age in the casein-fed rats and the soy-fed animals. Values shown are mean ± SEM. Symbols are: (•) casein protein diet; (○) soy protein diet. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

5 Figure 4 Proteinuria (UProtV) as a function of age (A) and proteinuria corrected for GFR (UProtV/GFR, B). Values shown are mean ± SEM. Symbols are: (•) casein protein diet; (○) soy protein diet. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

6 Figure 5 Plasma glucose concentration (A), plasma insulin concentration (B), each plotted as a function of age. Values shown are mean ± SEM. Symbols are: (•) casein protein diet; (○) soy protein diet. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

7 Figure 6 Plasma cholesterol concentrations (A) and plasma triglycerides (B), as a function of age. Symbols are: LDL and VLDL cholesterol levels in the (•) casein- and (○) soy-fed rats; HDL cholesterol levels in (▴) casein- and (▵) soy-fed rats. Values shown are mean ± SEM. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

8 Figure 7 Total plasma cholesterol concentration is shown as a function of body weight (A). The values plotted are the mean values obtained for each parameter and each group at 6, 10, 14, 18, 22 and 24 weeks of age. (B) Proteinuria (UProtV) is plotted as a function of plasma cholesterol using final individual animal values obtained at the end of the study. Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions

9 Figure 8 Protein excretion (UProtV) at the end of the study as a function of glomerular injury (glomerular sclerosis index). Symbols are: (•) casein protein diet; (○) soy protein diet. y = 908x - 140; r = 0.829; P < Kidney International  , DOI: ( /j x) Copyright © 2002 International Society of Nephrology Terms and Conditions


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