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Volume 93, Issue 1, Pages (January 2018)

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1 Volume 93, Issue 1, Pages 195-203 (January 2018)
Glomerular hyperfiltration is a predictor of adverse cardiovascular outcomes  Gianpaolo Reboldi, Paolo Verdecchia, Gioia Fiorucci, Lawrence J. Beilin, Kazuo Eguchi, Yutaka Imai, Kazuomi Kario, Takayoshi Ohkubo, Sante D. Pierdomenico, Joseph E. Schwartz, Lindon Wing, Francesca Saladini, Paolo Palatini  Kidney International  Volume 93, Issue 1, Pages (January 2018) DOI: /j.kint Copyright © 2017 International Society of Nephrology Terms and Conditions

2 Figure 1 Distribution of eGFR by the Chronic Kidney Disease Epidemiology Collaboration formula by sex and age. The 95th and 5th percentiles are shown by age quintiles. Hyperfiltration was defined as an eGFR above the age- and sex-specific 95th percentile, and low-filtration was defined as an eGFR below the 5th percentile. eGFR, estimated glomerular filtration rate. Kidney International  , DOI: ( /j.kint ) Copyright © 2017 International Society of Nephrology Terms and Conditions

3 Figure 2 Kaplan-Meier estimates for fatal and nonfatal cardiovascular (CV) events in patients with increased (hyperfiltration), normal, and low estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation. Hyperfiltration was defined as an eGFR above the age- and sex-specific 95th percentile, and low filtration was defined as an eGFR below the 5th percentile. Kidney International  , DOI: ( /j.kint ) Copyright © 2017 International Society of Nephrology Terms and Conditions

4 Figure 3 Adjusted hazard ratios for fatal and nonfatal cardiovascular events by eGFR decile (Chronic Kidney Disease Epidemiology Collaboration equation). Risk estimates are standardized to 53 years of age, male sex, no diabetes, nonsmoker, 205 mg/dl of total cholesterol, and an average 24-hour systolic blood pressure of 133 mm Hg. CV, cardiovascular; eGFR, estimated glomerular filtration rate; HR, hazard ratio; Ref., reference. Kidney International  , DOI: ( /j.kint ) Copyright © 2017 International Society of Nephrology Terms and Conditions


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