PERK activator treatment protects neurite network

Slides:

Advertisements

Similar presentations

The expressions of H19 and Igf1r are significantly decreased in the eutopic endometrium of women with endometriosis compared to those without endometriosis.

Advertisements

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.

Reduced scar formation in the injured GM of CCR2−/− mice

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Trx80 is generated by α‐secretases. A

PERK activator reduces behavioral deficits and neurodegeneration in vivo PERK activator reduces behavioral deficits and neurodegeneration in vivo A–CYoung.

PERK activator decreases pathological tau species in vivo

Dual anti‐Ang‐2 and anti‐VEGF therapy acts synergistic on vascular normalization and macrophage infiltration in experimental GBM Dual anti‐Ang‐2 and anti‐VEGF.

AβOs bind to and impact hypothalamic neurons Representative immunocytochemistry images of mature hypothalamic neurons in culture exposed to vehicle (Veh)

[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.

TFE3 regulates glucose homeostasis

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

Differential accumulation of substrates in vivo

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent pathway Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent.

Phenogenetic networks of genes linked to Alzheimer's and Parkinson's disease reveal concordant phenotypes Phenogenetic networks of genes linked to Alzheimer's.

Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.

Increased IFNγ producing CD4+ T cells in the spleen drives the enhanced splenic IFNγ on 6 dpi during concurrent co‐infection Increased IFNγ producing CD4+

No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO Cre+ mice No neurodegenerative phenotype observed in single Aph1a and Aph1bc cKO.

Supraphysiological ARSA activity in LV.hARSA‐injected NHP

AβOs induce hypothalamic inflammation, eIF2α phosphorylation and impaired insulin signaling A, BWestern blot analysis of eIF2α‐P levels in the hypothalamus.

TFE3 prevents diet‐induced obesity and metabolic syndrome

KLK7 is involved in the Aβ degradation activity

Loss of Ifnar1 signaling elicits inflammatory processes and angiogenesis in laser‐induced retinal damage Loss of Ifnar1 signaling elicits inflammatory.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Superior potency of EnAd expressing EpCAM BiTE in partially EnAd‐resistant cancer cell line Superior potency of EnAd expressing EpCAM BiTE in partially.

IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization AExperimental.

Cycling resident cardiomyocytes in the peri‐infarct area. A–C

Combination of OTX‐015 and PD does not induce overt toxicity

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Intra‐eWAT administration of FGF21 vectors in ob/ob mice

Nec‐1 inhibits the phosphorylation and aggregation of tau

High frequency and unique tumor‐initiating cells (TICs) in Pten/p53‐deficient mice Flow cytometry profiles of indicated tumors with the CD24 and CD49f.

Impaired ECM protein synthesis in infarcted area of S100a4cre+/− × Fstl1flox/flox mice Impaired ECM protein synthesis in infarcted area of S100a4cre+/−

IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics IR.

Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose tolerance Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose.

Akt inhibition with AZD5363 does not enhance the radiosensitivity of tumour cells in vitro Akt inhibition with AZD5363 does not enhance the radiosensitivity.

PERK activator decreases pathological tau species in vitro

Disease‐associated human WDR11 mutations are functionally defective

EGFL7 promoted density and maturation state of glioma vessels

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.

PGC‐1α‐independent regulation of the slow‐twitch muscle fiber program by miR‐499 PGC‐1α‐independent regulation of the slow‐twitch muscle fiber program.

Hccs downregulation induces apoptosome‐independent caspase‐9 activation in mitochondria.A–C.TUNEL assays on st30 embryos co‐injected with hccs‐MO and Apaf1‐MO.

Cochlear explant and slice preparation, and CDDP‐induced DNA damage and cell death in sensory hair cells and spiral ganglion neurons Cochlear explant and.

Safety profile of reversibly immortalised human mesoangioblasts

AAV8‐hAAT‐FGF21‐mediated increased energy expenditure and decreased fat accumulation in iBAT and iWAT AAV8‐hAAT‐FGF21‐mediated increased energy expenditure.

Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149.

TGFβ signaling activity in smooth muscle cells in human left main coronary arteries with various degrees of atherosclerosis TGFβ signaling activity in.

EnAd‐EpCAMBiTE shows reproducible activity within an expanded cohort of patient malignant peritoneal and pleural exudates EnAd‐EpCAMBiTE shows reproducible.

miR‐34a‐5p acts in PDGFRα+ cells to block lung alveolarization

Target engagement of the systemic Stat3 inhibitor in APP/PS1 mice

Quantification of phenotypes by genes and developmental stage

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

Therapeutic role of TR in HFD‐established diabetic mice

The CHCH domain is necessary for mitochondrial import of CHCHD10

DHEA shortens circadian period

Treatment with AZD5363 reduces the proportion of proliferating vascular endothelial cells and following RT, the influx of CD11b+ bone marrow‐derived cells.

Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts.

PKAN human neurons show altered oxidative status

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

Sox2 is essential for SLG regeneration following radiation injury

Effect of D‐Asp treatment on myelination and remyelination in cerebellar organotypic slices Effect of D‐Asp treatment on myelination and remyelination.

Catalytic activity of mTERT is needed for increased healthspan and life‐span extension in AAV9‐mTERT treated mice.A.Scheme of mTERT‐wt and mTERT‐DN, a.

GDF11 induces myotube atrophy in vitro

Single‐molecule dynamics of the active mutant, hDIA1(R1204X), in XTC cells Single‐molecule dynamics of the active mutant, hDIA1(R1204X), in XTC cells A–DGFP‐tagged.

CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.

Decreased brown adipose tissue (BAT) function in Deletors and the effects of nicotinamide riboside treatment for whole‐body metabolism, BAT, and liver.

Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids.

Presentation transcript:

PERK activator treatment protects neurite network PERK activator treatment protects neurite network Neurites were traced using the ImageJ plugin “Simple Neurite Tracer” by Mark Longair (http://fiji.sc/Simple_Neurite_Tracer) using bright‐field micrographs as shown in Fig 2E. Neuritic density was measured in n = 5 experiments per group on a scale of 0 (no neurites) to 100 (total surface area covered with neurites). Data are mean + SEM. Statistical analysis was by one‐way ANOVA with Tukey's post hoc test; **P < 0.01, ***P < 0.001. Julius Bruch et al. EMBO Mol Med. 2017;9:371-384 © as stated in the article, figure or figure legend