Presentation is loading. Please wait.

Presentation is loading. Please wait.

Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149.

Published by정비 증 Modified over 6 years ago

Similar presentations

Presentation on theme: "Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149."— Presentation transcript:

1 Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149 (B), MDAMB231 (C), HS578T (D) and BT20 (E) was assessed as in Fig 3.F.Inhibition of NAMPT using the potent inhibitor FK866 sensitizes DLD1 BRCA2−/− tumour cells to olaparib. Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149 (B), MDAMB231 (C), HS578T (D) and BT20 (E) was assessed as in Fig 3.F.Inhibition of NAMPT using the potent inhibitor FK866 sensitizes DLD1 BRCA2−/− tumour cells to olaparib. Viability was measured after 14 days of continuous exposure to FK866/olaparib. Error bars represent the SEM from three independent experiments. ANOVA analysis tables are shown in Supporting Information Table S4. Ilirjana Bajrami et al. EMBO Mol Med. 2012;4: © as stated in the article, figure or figure legend

Download ppt "Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149."

Similar presentations

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.
Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based.

Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based.
BRD4 expression levels are associated with sensitivity to BET inhibition in NRAS‐mutant melanoma BRD4 expression levels are associated with sensitivity.

BRD4 expression levels are associated with sensitivity to BET inhibition in NRAS‐mutant melanoma BRD4 expression levels are associated with sensitivity.
Analysis of the effect of loss of Brca2 on in vivo somatic mutation frequency and mutation type. Analysis of the effect of loss of Brca2 on in vivo somatic.

Analysis of the effect of loss of Brca2 on in vivo somatic mutation frequency and mutation type. Analysis of the effect of loss of Brca2 on in vivo somatic.
Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.

Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.
Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.
HDAC3 regulates AKT phosphorylation

HDAC3 regulates AKT phosphorylation
Trx80 is generated by α‐secretases. A

Trx80 is generated by α‐secretases. A
The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth A22Rv1.

The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth A22Rv1.
The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.
PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.

PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.
IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.

IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.
Interaction with Snail1 is required for LSD1 recruitment to the E‐cadherin promoter in vivo. Interaction with Snail1 is required for LSD1 recruitment to.

Interaction with Snail1 is required for LSD1 recruitment to the E‐cadherin promoter in vivo. Interaction with Snail1 is required for LSD1 recruitment to.
[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.

[68Ga]Pentixafor PET imaging of MM xenografts Real‐time PCR analysis of cxcr4 transcript expression levels in HeLa (negative control) and in MM cell lines.
Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides.

Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides.
Roles of systemic versus tumour SK1 in the regulation of local tumour growth and lung colonization/metastasis.A.Effects of siRNA‐mediated SK1 knockdown.

Roles of systemic versus tumour SK1 in the regulation of local tumour growth and lung colonization/metastasis.A.Effects of siRNA‐mediated SK1 knockdown.
Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent pathway Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent.

Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent pathway Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent.
BRD4 is associated with poor patient survival and constitutes a promising target for NRASMut melanoma BRD4 is associated with poor patient survival and.

BRD4 is associated with poor patient survival and constitutes a promising target for NRASMut melanoma BRD4 is associated with poor patient survival and.
ADAM8 maintains the aggressive phenotype of TNBC cells in 3D‐culture A–DCells were transfected with siRNAs as in Fig 2D and E for 24 h, and tested for.

ADAM8 maintains the aggressive phenotype of TNBC cells in 3D‐culture A–DCells were transfected with siRNAs as in Fig 2D and E for 24 h, and tested for.
Triple‐negative breast cancer (TNBC) cells in human express a specific gene signature and their self‐renewal depends on canonical Wnt/β‐catenin signalling.A.Human.

Triple‐negative breast cancer (TNBC) cells in human express a specific gene signature and their self‐renewal depends on canonical Wnt/β‐catenin signalling.A.Human.

Similar presentations

Ads by Google