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Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids.

Published byJessie Phillips Modified over 5 years ago

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Presentation on theme: "Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids."— Presentation transcript:

1 Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids AEffects of bazedoxifene (BZA) on IL11‐stimulated STAT3 activation (pSTAT3) in gastric (MKN1), colon (LIM2405), and breast (MDA‐MB‐231) cell lines.BEffects of bazedoxifene (BZA) on IL11‐stimulated STAT3 activation (pSTAT3) in primary cell cultures of isolated colon cancer epithelial cells of three individual colorectal cancer (CRC) patients.CmRNA expression levels of IL6, IL11, IL6R, IL11R, IL6ST encoding gp130 and SOC3, a STAT3‐regulated gene in epithelial cells derived from six colorectal cancer patients.DEffects of BZA treatment on IL11‐dependent growth of human colon cancer organoids. Organoids were cultured for 6 days in the presence of IL11 (50 ng/ml) and then for a further 7 days in IL11 plus the indicated concentration of BZA. Representative bright‐field microscopy images of organoid cultures at 7 days after BZA treatment. Scale bar = 300 μm.ERelative changes in organoid size after 7 day treatment with vehicle control or BZA as described in (D). Data are mean ± SEM, n = 3 individual cultures, one‐way ANOVA, Dunnett's comparison test. Source data are available online for this figure. Pathum Thilakasiri et al. EMBO Mol Med. 2019;emmm © as stated in the article, figure or figure legend

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