Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia J. Rømsing, S. Møiniche, J.B. Dahl British.

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Presentation transcript:

Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia J. Rømsing, S. Møiniche, J.B. Dahl British Journal of Anaesthesia Volume 88, Issue 2, Pages 215-226 (February 2002) DOI: 10.1093/bja/88.2.215 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 L’Abbé plots of mean visual analogue scale (VAS 0–100 mm) pain scores 1–8 h after surgery and of morphine consumption (μg kg−1 h−1) for rectal paracetamol (mg kg−1) vs placebo in trials for which data were available. Solid triangles: VAS score and morphine consumption were significantly (P<0.05) lower in the rectal paracetamol group compared with the placebo group. Solid squares: no significant difference in VAS scores or morphine consumption in the rectal paracetamol group compared with the placebo group. British Journal of Anaesthesia 2002 88, 215-226DOI: (10.1093/bja/88.2.215) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 L’Abbé plot of mean VAS score 4–6 h after surgery for parenteral paracetamol (propacetamol) vs placebo in trials for which data were available. Solid triangles: VAS scores were significantly (P<0.05) lower in the parenteral paracetamol group compared with the placebo group. Solid squares: no significant difference in VAS scores in the parenteral paracetamol group compared with the placebo group. British Journal of Anaesthesia 2002 88, 215-226DOI: (10.1093/bja/88.2.215) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 3 Weighted mean difference (WMD) with 95% confidence intervals (95% CI, horizontal lines) in VAS scores 4–6 h after surgery between the parenteral paracetamol groups and the placebo groups in eight trials. References 26 and 28 were not included in the calculations because of lack of dispersion measures. ‘Total’ indicates the results of pooling all the trials. Numbers in the column headed ‘Weight’ indicate the weight of the individual trials in the analysis, taking into account study size and standard deviations of VAS scores. British Journal of Anaesthesia 2002 88, 215-226DOI: (10.1093/bja/88.2.215) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 4 L’Abbé plots of mean/median VAS scores 4–8 h after surgery and of morphine or tramadol consumption (mg per 24 h) for paracetamol vs paracetamol and an NSAID in trials for which data were available. Solid triangles: VAS scores and morphine consumption were significantly (P<0.05) lower in the paracetamol plus NSAID group compared with the paracetamol group. Solid squares: no significant difference in VAS scores and morphine consumption in the paracetamol plus NSAID group compared with the paracetamol group. British Journal of Anaesthesia 2002 88, 215-226DOI: (10.1093/bja/88.2.215) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 5 L’Abbé plots of mean/median VAS scores 4–8 h after surgery and of morphine or tramadol consumption (mg per 24 h) for an NSAID vs an NSAID and paracetamol in trials for which data were available. Solid triangles: VAS scores and morphine consumption were significantly (P<0.05) lower in the NSAID and paracetamol group compared with the NSAID group. Solid squares: no significant difference in VAS scores and morphine consumption in the NSAID and paracetamol group compared with the NSAID group. British Journal of Anaesthesia 2002 88, 215-226DOI: (10.1093/bja/88.2.215) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions