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Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs  Sonja A. Aghighi, Andrea Tipold, Marion.

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Presentation on theme: "Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs  Sonja A. Aghighi, Andrea Tipold, Marion."— Presentation transcript:

1 Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs  Sonja A. Aghighi, Andrea Tipold, Marion Piechotta, Piotr Lewczuk, Sabine B.R. Kästner  Veterinary Anaesthesia and Analgesia  Volume 39, Issue 6, Pages (November 2012) DOI: /j x Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

2 Figure 1 Postoperative pain determined by the Glasgow Composite Measure Pain Scale (CMPS-SF) over 5 days. Diagram contains data of 63 dogs in the postoperative period after hemilaminectomy. Dogs are treated with gabapentin (10 mg kg−1 orally every 12 hours) or placebo in addition to opioid background analgesia. Data are presented as box plots over time. The box contains the interquartile range (mean 50% of data). Whiskers show data from minimum to maximum. The horizontal line inside the box marks the median. *Significant (p < 0.05) difference to baseline value at 0.5 days. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

3 Figure 2 Postoperative pain assessed using a Visual Analogue Scale (VAS) over 5 days following hemilaminectomy in dogs treated with gabapentin or placebo in addition to opioid background analgesia. Data are presented as mean (SD). * significant (p < 0.05) difference to baseline value at 0.5 days. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

4 Figure 3 Mean arterial blood pressure (MAP) of dogs for 5 days after hemilaminectomy, treated with gabapentin or placebo in addition to opioid background analgesia. Data are presented as mean (SD). Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

5 Figure 4 Postoperative bladder function of 63 dogs for 5 days after hemilaminectomy. The first column of each time point represents the gabapentin group (GBP) (n = 31) and the second column the placebo group (P) (n = 32). Data are presented as percentages. *significant (p < 0.05) difference to baseline value at 0.5 days. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

6 Figure 5 Postoperative cortisol serum concentrations at 24, 48 and 72 hours after hemilaminectomy. Data are presented as boxplots. The box contains interquartile range (mean 50% of data). The horizontal line inside the box marks the median. Whiskers show data from minimum to maximum. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

7 Figure 6 Gabapentin serum concentrations at 24 and 72 hours post surgery in 29 gabapentin treated dogs versus pain score (shortform of Glasgow Composite Measure Pain Scale, CMPS-SF). Dogs are divided into two groups: serum concentrations above or below 3 μg mL−1. Data are presented as boxplots. The box contains interquartile range (mean 50% of data). The horizontal line inside the box marks the median. Whiskers show data from minimum to maximum. Veterinary Anaesthesia and Analgesia  , DOI: ( /j x) Copyright © 2012 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions


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