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Antifibrinolytics in cardiac surgical patients receiving aspirin: a systematic review and meta-analysis  D.R. McIlroy, P.S. Myles, L.E. Phillips, J.A.

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Presentation on theme: "Antifibrinolytics in cardiac surgical patients receiving aspirin: a systematic review and meta-analysis  D.R. McIlroy, P.S. Myles, L.E. Phillips, J.A."— Presentation transcript:

1 Antifibrinolytics in cardiac surgical patients receiving aspirin: a systematic review and meta-analysis  D.R. McIlroy, P.S. Myles, L.E. Phillips, J.A. Smith  British Journal of Anaesthesia  Volume 102, Issue 2, Pages (February 2009) DOI: /bja/aen377 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Flow chart of search and selection process for identification of studies for inclusion in meta-analysis. British Journal of Anaesthesia  , DOI: ( /bja/aen377) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Pooled estimates of mean postoperative chest-tube drainage (ml): antifibrinolytic vs placebo. Results are presented as mean difference with 95% confidence interval represented by horizontal line. Sub-group analysis is presented for both aprotinin vs placebo and lysine analogue vs placebo. A random effects model has been used. The size of the square represents the relative weighting of a study and is positioned at the point estimate of mean difference. Diamond markings represent 95% confidence interval for pooled summary effect estimate within each subgroup and as a total measure of effect (lower diamond). British Journal of Anaesthesia  , DOI: ( /bja/aen377) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Pooled estimates of proportion of patients receiving any allogeneic blood products: antifibrinolytic vs placebo. Results are presented as odds ratio with 95% confidence interval represented by horizontal line. Sub-group analysis is presented for both aprotinin vs placebo and lysine analogue vs placebo. A random effects model has been used. The size of the square represents the relative weighting of a study and is positioned at the point estimate of the odds ratio. Diamond markings represent 95% confidence interval for pooled summary effect estimate within each subgroup and as a total measure of effect (lower diamond). British Journal of Anaesthesia  , DOI: ( /bja/aen377) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Pooled estimates of proportion of patients undergoing surgical re-exploration: antifibrinolytic vs placebo. Results are presented as odds ratio with 95% confidence interval represented by horizontal line. Sub-group analysis is presented for both aprotinin vs placebo and lysine analogue vs placebo. A random effects model has been used. The size of the square represents the relative weighting of a study and is positioned at the point estimate of the odds ratio. Diamond markings represent 95% confidence interval for pooled summary effect estimate within each subgroup and as a total measure of effect (lower diamond). British Journal of Anaesthesia  , DOI: ( /bja/aen377) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

6 Fig 5 Pooled estimates of proportion of patients with a thrombotic complication: antifibrinolytic vs placebo. Results are presented as odds ratio with 95% confidence interval represented by horizontal line. Sub-group analysis is presented for both aprotinin vs placebo and lysine analogue vs placebo. A random effects model has been used. The size of the square represents the relative weighting of a study and is positioned at the point estimate of the odds ratio. Diamond markings represent 95% confidence interval for pooled summary effect estimate within each subgroup and as a total measure of effect (lower diamond). British Journal of Anaesthesia  , DOI: ( /bja/aen377) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

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