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C. A. Deegan, D. Murray, P. Doran, P. Ecimovic, D. C. Moriarty, D. J

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Presentation on theme: "C. A. Deegan, D. Murray, P. Doran, P. Ecimovic, D. C. Moriarty, D. J"— Presentation transcript:

1 Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro† 
C.A. Deegan, D. Murray, P. Doran, P. Ecimovic, D.C. Moriarty, D.J. Buggy  British Journal of Anaesthesia  Volume 103, Issue 5, Pages (November 2009) DOI: /bja/aep261 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Mean (sd) VAS pain scores in patients after breast cancer surgery with sevoflurane anaesthesia and opioid analgesia (sevoflurane/opioid) or combined propofol/paravertebral anaesthesia and paravertebral analgesia (propofol/paravertebral). Pain scores were significantly lower at 1 (P=0.03) and 2 h (P=0.02) in the propofol/paravertebral group. British Journal of Anaesthesia  , DOI: ( /bja/aep261) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Mean percentage change in MDA-MB-231 cell proliferation from pre- to postoperative values in the sevoflurane/opioid group compared with the propofol/paravertebral group after treatment with patient serum at 0%, 2%, 5%, and 10% concentrations. Compared with values in the sevoflurane/opioid group, proliferation was reduced significantly at 10% patient serum concentration in the propofol/paravertebral group (P=0.01). British Journal of Anaesthesia  , DOI: ( /bja/aep261) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Effect of exposure of MDA-MB-231 cells to pre- and postoperative patient serum on cell migration. There was no significant change in mean percentage change of pre- to postoperative cellular migration after treatment of MDA-MB-231 cells with serum from either group. British Journal of Anaesthesia  , DOI: ( /bja/aep261) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Mean percentage change of wound closure between pre- and postoperative serum treatment at t=6, 12, and 24 h. There was no significant change in speed of wound closure from pre- to postoperative values after treatment of MDA-MB-231 cells with patient serum between the groups at t=6 or 12 h. At 24 h post-wounding, all wounds were completely closed. British Journal of Anaesthesia  , DOI: ( /bja/aep261) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions


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