Comparison of N. gonorrhoeae gene expression during infection in men and women in vivo. Comparison of N. gonorrhoeae gene expression during infection in.

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Comparison of N. gonorrhoeae gene expression during infection in men and women in vivo. Comparison of N. gonorrhoeae gene expression during infection in men and women in vivo. (A) Variance in global expression in each specimen from men and women. The first principal component (PC1 [x axis]) had a variance of ~26%, and the second principal component (PC2 [y axis]) had a variance of ~14%. (B) Functional enrichment of genes with significant changes in expression levels in men and women. Genes were differentially expressed if the q value was ≤0.05 and the fold change was ≥2. Blue bars represent genes with increased expression in vivo in men compared to women. Red bars represent genes with increased expression in vivo in women compared to men. *, significant enrichment among genes increased in vivo in men; #, significant enrichment among genes increased in vivo in women. Kathleen Nudel et al. mSphere 2018; doi:10.1128/mSphereDirect.00312-18