1. Fig. 7 Correlation of NHP and human ISGs.
Correlation of NHP and human ISGs. Analysis of the fold induction correlation with regard to the ISG response in NHPs to human fatalities. (A) Correlation plot of all ISGs that are identified as being differentially regulated at any time point in the NHP data set. The x axis is the log2 fold change for the Normal animals at day 6 after exposure, and the y axis is the log2 fold change for the Delayed animals at day 10 after exposure (red points and line) or the Late animals at day 21 after exposure (blue points and line). The lines are linear fits. (B) Correlation of the human fatal cases (log2 fold change compared to controls) on the x axis and the fold change of the Late group (log2 fold change compared to controls) at day 21 after exposure. The line represents a linear fit of the data. (C) Correlation plot similar to (B) but with only the early ISGs shown. (D) Table of the genes in (C) with their comparison of the log2 fold change in humans and NHPs. Reported P values are from a correlation test.
Emily Speranza et al., Sci Transl Med 2018;10:eaaq1016
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