1. Differential relative abundance of major taxa for successive pairwise comparisons.
Differential relative abundance of major taxa for successive pairwise comparisons. All possible comparisons of cohorts revealed 102 OTUs that were reproducibly different between at least one pair of cohorts. These were grouped into 26 classified genera and one set containing all unclassified OTUs. The plots show all OTUs in these 26 genera for pairwise comparisons between each successive age group pair: 3 to 6 versus 8 to 12, 8 to 12 versus 13 to 14, 13 to 14 versus 19 to 24, 19 to 24 versus 30 to 50, 30 to 50 versus 60 to 79, and 60 to 79 versus >94. Each comparison plot shows a point for each OTU binned by genus with the log2 standardized difference, the “effect” measure determined by ALDEx2 (24, 39), between the two groups on the x axis. Points are colored as red or blue if they have an effect size of ≥1 for the comparison. An effect size greater than 1 indicates that the OTU will be reliably found to have a greater difference between groups than dispersion within either group (24). Equivalent plots for comparisons at different taxonomic levels are shown in Fig. S6.
Gaorui Bian et al. mSphere 2017; doi: /mSphere