1. Modules with causal links to ALS are associated with inflammation and enriched with TDP‐43 protein–protein interactions (PPIs)‏
Modules with causal links to ALS are associated with inflammation and enriched with TDP‐43 protein–protein interactions (PPIs) Enrichment of TDP‐43 PPIs is displayed in this heatmap with results from TDP‐43 PPI from BIOGRID and those from published global analysis of TDP‐43 interacting proteins (Freibaum et al, 2010), with protein co‐expression modules listed across the horizontal axis. Colors on heat map indicate enrichment (red) or no significant over‐representation (white) for gene membership. Numbers displayed on the heatmaps represent positive signed −log10(BH‐adjusted P‐values).M2 (blue nodes) and M6 (red nodes) modules represented by proteins with high co‐expression (gray lines) and TDP‐43 PPIs (yellow lines). Several genes that have been previously linked to ALS‐FTD are also highlighted by their colored module membership (inset).
Mfon E Umoh et al. EMBO Mol Med. 2017;emmm
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