Figure 5 The role of Ly6Chi and Ly6Clo monocytes

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Figure 5 The role of Ly6Chi and Ly6Clo monocytes in the development of different mouse models of arthritis Figure 5 | The role of Ly6Chi and Ly6Clo monocytes in the development of different mouse models of arthritis. a | Ly6Clo monocytes drive the development of sterile inflammatory arthritis. Transfer of serum from K/B × N mice causes a CCR2-independent influx of Ly6Clo monocytes, which give rise to MHCII+ inflammatory macrophages. These polarize towards an alternatively activated phenotype (MHCII−) during the development of arthritis. Tissue-resident synovial macrophages (largely MHCII−) limit the development of arthritis. b | Ly6Chi monocytes drive the development of antigen-induced inflammatory arthritis. Methylated bovine serum albumin (mBSA) challenge causes a CCR2-dependent influx of Ly6Chi monocytes, which in turn leads to an increase in inflammatory MHCII+ macrophage numbers. Proportions of anti-inflammatory CD206+ macrophages are decreased in inflamed knees compared with control knees treated with phosphate-buffered saline (PBS). Ly6C, lymphocyte antigen 6C2. Udalova, I. A. et al. (2016) Macrophage heterogeneity in the context of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.91