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Figure 4 Model of changes in the serum levels
of fibroblast growth factor 23 (FGF-23), 1,25 dihydroxyvitamin D (1,25D), parathyroid hormone (PTH) and phosphate during progression of chronic kidney disease Figure 4 | Model of changes in the serum levels of fibroblast growth factor 23 (FGF-23), 1,25 dihydroxyvitamin D (1,25D), parathyroid hormone (PTH) and phosphate during progression of chronic kidney disease. As glomerular filtration rate (GFR) declines, the level of FGF-23 is the first to increase, followed by decreasing levels of 1,25D and increasing levels of PTH. The increase in phosphate levels occurs at a much lower level of kidney function than the changes in the other parameters. Vervloet, M. G. et al. (2016) The role of phosphate in kidney disease Nat. Rev. Nephrol. doi: /nrneph
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