Natalija Novak, MD Journal of Allergy and Clinical Immunology

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Presentation transcript:

An update on the role of human dendritic cells in patients with atopic dermatitis Natalija Novak, MD Journal of Allergy and Clinical Immunology Volume 129, Issue 4, Pages 879-886 (April 2012) DOI: 10.1016/j.jaci.2012.01.062 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Schematic overview of DC subtypes in nonlesional and lesional skin of patients with AD. The pattern of DC subtypes in nonlesional versus lesional skin of patients with AD is shown. LCs predominate in the epidermis of nonlesional skin, few LCs are also present in the dermis, and the main population of the dermis are dermal DCs. These cells are supplemented by inflammatory DC subtypes in the epidermis and dermis, as well as pDCs in the dermis, in lesional skin of patients with AD. dLC, Dermal langerin-positive dendritic cell; IDDC, inflammatory dendritic dermal cell; Mo, monocyte. Journal of Allergy and Clinical Immunology 2012 129, 879-886DOI: (10.1016/j.jaci.2012.01.062) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Summary of the versatile functions of DCs in skin of patients with AD. Pathways modified in patients with AD involving skin DCs are shown. Mechanical damage and skin barrier impairment allow penetration of the upper parts of the skin by allergens and microbial components, which come into contact with DCs. TSLP-stimulated DCs amplify TH2 polarization, and inflammatory DC subtypes are recruited to the skin and predominate in the epidermis and dermis. In addition, regulatory pathways counteracting allergic skin inflammation are modified and attenuated in patients with AD as well. Eo, Eosinophil; INF-R, IFN-γ receptor; IP-10, interferon-inducible protein 10; M, mast cell; p-STAT1, phosphorylated signal transducer and activator of transcription 1; Treg, regulatory T cell. Journal of Allergy and Clinical Immunology 2012 129, 879-886DOI: (10.1016/j.jaci.2012.01.062) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions