1. Endotype-driven care pathways in patients with chronic rhinosinusitis
Claus Bachert, MD, PhD, Nan Zhang, MD, PhD, Peter W. Hellings, MD, Jean Bousquet, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 141, Issue 5, Pages (May 2018)
DOI: /j.jaci
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1 Endotypes of CRS and clinical consequences.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Therapeutic approaches according to endotypes. CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells; FESS, functional endoscopic sinus surgery; GCS, glucocorticosteroids.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Mechanisms of action of biologics in patients with CRSwNP. DC, Dendritic cell; ECP, eosinophil cationic protein; EDN, eosinophil-derived neurotoxin; Eos, eosinophils; EPO, eosinophil peroxidase; IL-4Rα, IL-4 receptor α; TSLP, thymic stromal lymphopoietin.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
ICPs for CRS (regional differences and new studies can lead to changes of the ICP). FESS, Functional endoscopic sinus surgery.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions