1. Endotoxin and the lung: Insight into the host-environment interaction
Jaspal Singh, MD, David A. Schwartz, MD, MPH 
Journal of Allergy and Clinical Immunology 
Volume 115, Issue 2, Pages (February 2005)
DOI: /j.jaci
Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2. Fig 1
Environmental endotoxin, depending on dose and timing, can result in predominantly either an adaptive or innate immune response. Endotoxin directly and indirectly stimulates lung resident (dendritic) and recruited (hematopoietic) cells, which in turn interact with Treg cells. The Treg cells modulate the adaptive immune system to develop clinical allergy and/or asthma. Individual genetic predilection, modified by other factors of host susceptibility, mediates this complex interaction.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions