1. Astrotactin 1–derived peptide: A new skin-penetrating peptide against inflammatory skin diseases 
Laurent L'homme, PhD, David Dombrowicz, PhD 
Journal of Allergy and Clinical Immunology 
Volume 141, Issue 1, Pages (January 2018)
DOI: /j.jaci
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Role of AP-rPTP on IL-4 receptor (IL-4R), IL-13 receptor (IL-13R), and IL-23 receptor (IL-23R) signaling. Binding of cytokine to its receptor induces the recruitment of JAKs. JAKs are phosphorylated, either through autophosphorylation or phosphorylation by other kinases, which increases their kinase activity. JAKs phosphorylate tyrosine residues on the cytoplasmic tail of the receptor, allowing STAT recruitment (step not illustrated). STATs are then phosphorylated by JAKs. STAT phosphorylation results in dimerization, followed by nuclear translocation, during which they will regulate gene expression (steps not illustrated). AP-rPTP dephosphorylates various proteins, including JAK1, JAK3, STAT3, and STAT6, interfering with IL-4, IL-13, and IL-23 signaling at different levels.
Journal of Allergy and Clinical Immunology  , 86-88DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions