Anti inflammatory drugs

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Presentation transcript:

Anti inflammatory drugs

What is the inflammation What is the inflammation ? Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function.

Types of inflammation: Acute inflammation It is associated with increased vascular permeability, capillary infiltration and emigration of leukocytes.  

Chronic inflammation   It is associated with infiltration of mononuclear immune cells, macrophages, monocyts, neutrophils, fibroblast activation, proliferation (angiogenesis) and fibrosis. for example : rheumatoid arthritis (RA).

herbs have anti-inflammatory properties: Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity.

Aconitum heterophyllum : Origin: dried root of Aconitum heterophyllum family Valeraneaceae. Active constituent : alkaloids glycosides flavnoids and sterols. Uses: It is used for the treatment of diseases of: nervous system digestive system fever and rheumatism.

Adhatoda vasica (Acanthaceae): Origin: is an indigenous herb of Adhatoda vasica family Acanthaceae. Active constituent : alkaloids tannins flavnoids terpenes sugars and glycosides. Uses: treating cold, cough, whooping cough. chronic bronchitis,asthma. sedative expectorant, antispasmodic. anthelmintic, rheumatism . rheumatic painful and nflammatory swellings. *The drug is employed in different forms such as freshjuice,decoction, infusion and powder. It is also given as alcoholic extract and liquid extract or syrup.

Ginger: origin : dried "root" or the rhizome, of the plant Zingiber officinale .family Zingiberaceae. * Jamaican ginger was the traditional medical form of this root, and has been used to treat rheumatoid arthritis pain. * Also ginger supplements were found to reduce the markers of colon inflammation. Active constituent : resin (gingerols- shogaols) volatile oil (zingiberine) starch-protein –vitamins use: Antioxidant activity Anti-inflammatory activity Anti-tumour activity Anti-microbial activity

Cannabis: origin : dried tops of cultivated female plant of cannabis sativa family cannabinaceae. Active constituent : cannabinnoid called cannabichromene. Uses : anti-inflammatory. Cancer Prevention.  relief for stress and anxiety.