(fold change of miR-cont)

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(fold change of miR-cont) Fig. S1 A B A549 H1975 EGFR GAPDH 1 2 1 2 1: miR-cont 2: miR-218 EGFR GAPDH A549 H1975 1 2 1 2 p-STAT3 1: siR-cont 2: siR-EGFR C (fold change of miR-cont) Cell Number Fig. S1 (A) A549 and H1975 cells were transfected with miR-cont or miR-218. Protein levels of EGFR were examined by western blotting 36 hours after transfection. (B) A549 and H1975 cells were transfected with siR-cont or siR-EGFR. Protein levels of EGFR and pSTAT3 were examined by western blotting 36 hours after transfection. (C) Cell proliferation in H1975 and A549 cells was determined 48 hours after transfection of siR-EGFR or siR-control.

Patients with lung adenocarcinoma (441 cases in TCGA cohort) A Fig. S2 Patients with lung adenocarcinoma (441 cases in TCGA cohort) A Log2 of IL6R r=-0.46, p < 0.01 Log2 of miR-218 B Log2 of JAK3 r=-0.40, p < 0.01 Fig. S2 Correlation of IL-6R/JAK3 and miR-218 in patients with lung adenocarcinoma in TCGA cohort. Log2 of miR-218