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A B CDK2 CDK2 inhibition P Activated KRAS P CP110 CP110

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Presentation on theme: "A B CDK2 CDK2 inhibition P Activated KRAS P CP110 CP110"— Presentation transcript:

1 A B CDK2 CDK2 inhibition P Activated KRAS P CP110 CP110
Supplemental Fig. S3 A CDK2 CDK2 inhibition P Activated KRAS P CP110 CP110 CP110 Anaphase catastrophe Normal cell division Anaphase catastrophe B A549 Hop62 HA- CP110 HA- CP110 Actin Actin WT-CP110 48h Vector 24h Mut-CP110 24h Vector 48h WT-CP110 48h Mut-CP110 48h Vector 24h WT-CP110 24h Vector 48h WT-CP110 24h Supplemental Fig.4 CP110 was successfully overexpressed in A549, Hop62, H522 and H460 cells. Exogenous CP110 was detected with anti-HA antibody after 24 and 48 h of transfection. A representative Western blot for each cell line was shown H522 H460 HA- CP110 HA- CP110 Actin Actin Vector 24h WT-CP110 24h Vector 48h WT-CP110 48h Vector 24h WT-CP110 24h Vector 48h WT-CP110 48h Supplemental Fig. S3. (A) Schematic diagram showing the relationship between CDK2, CP110, activated KRAS and anaphase catastrophe. (B) Engineered overexpression of CP110 was detected in A549, Hop62, H522 and H460 cells (versus control transfectants) using anti-HA antibody after 24 and 48 hours of transfection. A representative immunoblot for each cell line is displayed.

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