1. IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.
IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes. HepG2 cells were treated as in Fig. 5. Western blots of IRS-1 were probed with anti-p85 antibody. A representative blot of four independent experiments is shown. Results of the four experiments were quantitated by densitometry and expressed as fold increase over IL-6-free basal ± SD. Inset: data were expressed as fold increase of control and IL-6-treated cells relative to their respective insulin-free basal levels.
Joseph J. Senn et al. Diabetes 2002;51:
©2002 by American Diabetes Association