Community Health Center Networked Research One Strategy to Reduce Oral Health Disparities NATIONAL PRIMARY ORAL HEALTH CONFERENCE Nashville Donald DeNucci, DDS, MS Center for Clinical Research National Institute of Dental And Craniofacial Research June 17-18, 2005

NIDCR Research Update Strategic Initiatives CHC Conference Nashville Nov 2009 NIDCR Research Update Strategic Initiatives Advance the understanding of oral and craniofacial diseases Develop new approaches to the diagnosis and treatment of these conditions Ensure adequate personnel and infrastructure to accomplish this mission Enhance the translation of research results into clinical practice Document and monitor oral and craniofacial disease Eliminate health disparities in oral and craniofacial diseases

NIDCR Disparities Program CHC Conference Nashville Nov 2009 NIDCR Disparities Program The National Institute of Dental and Craniofacial Research A Plan to Eliminate Craniofacial, Oral, and Dental Health Disparities

NIDCR Disparities Centers Populations Targeted CHC Conference Nashville Nov 2009 NIDCR Disparities Centers Populations Targeted All race/ethnic populations with health disparities including African American, Hispanic (Mexican, Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin regardless of race), American Indian or Alaskan Native, Asian or Pacific Islanders Low income rural (e.g., Appalachian) or urban dwellers Special needs populations (e.g., physically or mentally disabled) People living with HIV/AIDS The elderly Home-bound and institutionalized individuals

NIDCR Disparities Centers CHC Conference Nashville Nov 2009 NIDCR Disparities Centers Boston University University of California, San Francisco University of Colorado University of Florida University of Washington

NIDCR Disparities Centers Topical areas of interest CHC Conference Nashville Nov 2009 NIDCR Disparities Centers Topical areas of interest Early Childhood Caries Periodontal Disease Oral and Pharyngeal Cancer

CHC Conference Nashville Nov 2009 NIDCR - Sponsored Practice-Based Research Networks (PBRN) Designed to gather “real-world” evidence for the prevention and treatment of oral diseases

General Dental Practice-Based Research Networks Cooperative Agreements Awarded 5/01/2005 $75 million over 7 years Awardees NYU PEARL Network Universities of Alabama / Florida DPBRN Network Permanente Dental Associates Health Partners Georgia Mississippi Scandinavia Universities of Washington / Oregon NW PRECEDENT Network TransPBRN entity comprising all three networks CONDOR Network

Dental Practice-Based Research Networks - Purpose CHC Conference Nashville Nov 2009 Dental Practice-Based Research Networks - Purpose Answer questions facing general dental practitioners in the routine care of their patients Strengthen knowledge base for making clinical decisions Observational studies Clinical trials Establish/use a flexible, adaptable electronic network/platform for connectivity, data sharing, & communication within and between dental and medical networks

Dental Practice-Based Research Networks-Objectives CHC Conference Nashville Nov 2009 Dental Practice-Based Research Networks-Objectives Stimulate research proposals from practicing dentists and dental hygienists (i.e., practitioner-investigators) Primary objectives: • Conduct 16-22 short-term clinical studies over 7 years • Emphasis on effectiveness of oral health treatment & disease prevention (Clinical Effectiveness Research) • Clear & clinically meaningful outcomes Secondary objective: Provide data on disease and treatment trends and obtain estimates of the prevalence of less common conditions

Snapshot of PBRNs’ Current Membership, by State CHC Conference Nashville Nov 2009 Snapshot of PBRNs’ Current Membership, by State

PBRN Research Activities – Year Five CHC Conference Nashville Nov 2009 PBRN Research Activities – Year Five DPBRN: Studies are focusing on treatment strategies for treating early carious lesions, patient satisfaction with dental restorations, reasons for replacing dental restoration, diabetes screening, smoking cessation PEARL: Studies are focusing on treatment strategies for advanced dental caries, survival of endo treated teeth , sensitive teeth, analgesic prescribing practices, periodontal disease diagnosis, oral cancer screening PRECEDENT: Studies focusing on caries risk assessment, dental pulp capping, wisdom tooth removal, orthodontic anchorage devices, white spot lesions (early caries)

CHC Conference Nashville Nov 2009 NIH Funding Announcement (FOA) ARRA RC4 Limited Competition : Building Sustainable Community-Linked Infrastructure to Enable Health Science Research NIH has designated up to $30 million in FY2009-2010 to fund 30 or more grants Purpose is to fund projects to develop infrastructure for productive and sustainable academic-community research partnerships (not to fund research projects) Individual grants are limited to a maximum of $1 million in total costs for the grant period Projects may not exceed three years RFA-OD-09-010 Visit www.NIH.GOV for more details

Institutionally-based Research Publications

Practice-based Research Publications Policy Development Clinical Guidelines

Analysis of Data Generated by Patient Care Publications Policy Development Clinical Guidelines

CHC Conference Nashville Nov 2009 Donald J. DeNucci, D.D.S., M.S. Program Director Practice Based Research Networks Center for Clinical Research National Institute of Dental and Craniofacial Research 6701 Democracy Blvd., Room 632 Telephone: 301-451-5096 Fax: 301-480-8322 E-mail:  denuccid@nidcr.nih.gov