1. A group of dental practices that has affiliated to investigate research questions and to engage in sharing experiences and expertise. What is a dental practice-based research network (PBRN)?

2. A group of dental practices that has affiliated to investigate research questions and to engage in sharing experiences and expertise. The network conducts research that is done by and about the “real world” of daily clinical practice, where the overwhelming majority of the population receives its dental care. What is a dental practice-based research network (PBRN)?

3. Laboratory Clinical trials Practice-basedCommunity- research in academic researchbased settingsresearch when treatment is…____ not ready for not ready for not ready for not ready for humans 1 patients practices communities 1 most of the “not ready” terms adapted with revision from James W. Mold, MD, MPH How is PBRN research different from other types of research?

4. Rigorous but not relevant

5. A knowledge explosion

6. 6  passive generation of knowledge usually either does not work or is very slow  substantial difference between the health care that we are eligible for and the care that we actually receive References Quality improvement: science and action. Circulation 2009; 119: 1962-1974. How can primary care cross the quality chasm? Annals Fam Med 2009; 7(2): 164-169. The neglected purpose of comparative-effectiveness research. N Engl J Med 2009; 360(19): 1929-1931. Life cycle of translational research for medical interventions. Science 2008; 321:1298- 1299. Clinical research to clinical practice – lost in translation? N Engl J Med 2003; 349(9): 868- 874. Can we rely on generation of new knowledge to improve public health?

7. Source: Practice-based research …J Am Med Assoc 2007; 297: 403-406. Dissecting the “translational” process

8. “If we want more evidence-based practice, we need more practice-based evidence.” –Lawrence W. Green, DrPH seeing knowledge translation as a one-way street and blaming the health care providers is not the solution better delivery of established therapies would save more lives than the next innovation in therapy References Quality improvement: science and action. Circulation 2009; 119: 1962-1974. How can primary care cross the quality chasm? Annals Fam Med 2009; 7(2): 164-169. Moving things forward…

9. We need to engage the practitioners and their patients in the whole research process

10. NIDCR funded three dental PBRNs in 2005

11. The DPBRN regions

12.  Would we really be able to recruit a large number of dentist practitioners?  Would we really be able to establish the necessary regulatory and contractual relationships?  Would dentists in busy clinical practice really be effective at doing studies in their practices?  Would practitioner-investigators really contribute ideas for research projects?  Would they really participate at every step of the research process? Many skeptics asked …

13. Practical science done about, in, and for the benefit of “real world" clinical practice. A network about, with, and for practitioner- investigators and their patients

14. Benefits of participating as communicated by practitioner-investigators Provides a focus for clinical excellence by devoting increased short-term attention to one particular area of clinical practice at a time Can improve the logistics of daily clinical operations, serve as a team builder for practice staff, and engage the entire staff in the excitement of discovery and quality improvement Projects can improve the quality of dental care by contributing to the scientific basis for the dental procedures that are their focus

15. Benefits of participating as communicated by practitioner-investigators Provides venues for collegial interactions and exchange of ideas with fellow practitioner-investigators; become part of a community of learning and camaraderie Receive CE credit for attendance at DPBRN annual meetings and participating in training and certification activities for specific DPBRN studies Receive certificates suitable for framing and display in the office

16. Benefits of participating as communicated by practitioner-investigators Receive financial remuneration for the time spent doing research Allows practitioner-investigators to see what is effective in their practices in comparison to other practices – using results that are presented anonymously Practitioner-investigators decide what studies are done and what treatment is done - not third parties Potential to present at local, state, national, and international dental meetings and research conferences

17. Benefits as communicated by DPBRN practitioner- investigators themselves Distinguishes the practice from other practices, acting as a practice promoter or practice builder Increases the practice's visibility and stature among dental patients Enhances communication with patients by showing that the practitioner-investigator cares about the scientific basis of clinical practice Expands the vision for patient care by including a formalized research and quality improvement component to it

18. 18 Data collection completed (14 studies) - “Dental tobacco control randomized clinical trial” - “Practice-based root canal treatment effectiveness” - “Assessment of caries diagnosis and caries treatment” - “Case-control study of osteonecrosis of the jaws” - “Retrospective cohort study of osteonecrosis of the jaws” - “Reasons for placing the 1 st restoration on permanent tooth surfaces” - “Reasons for replacement or repair of dental restorations” - “Patient satisfaction with dental restorations” - “Assessing impact of participation in practice-based research on clinical practice and patient care” - “Prevalence of questionable occlusal caries lesions” - “Blood glucose testing in dental practice” - “CONDOR TMJD study” - “Development of a patient-based provider intervention for early caries management” - “Peri-operative pain and root canal therapy” Update on DPBRN studies as of February 2011

19. 19 In data collection phase (5 studies) - “Longitudinal study of dental restorations placed on previously un-restored surfaces” - “Longitudinal study of questionable occlusal caries lesions” - “Longitudinal study of repaired or replaced dental restorations” - “Hygienists’ internet tobacco cessation randomized clinical trial” - “Persistent pain and root canal therapy” Update on DPBRN studies as of February 2011

20. 20 Number of units in 16 DPBRN studies to date Study title# of practitioner- investigators Number of patients, procedures or other entities Dental tobacco control randomized clinical trial19011,898 patients Practice-based root canal treatment effectiveness1384 patients, 174 treated teeth Assessment of caries diagnosis and caries treatment565-- Reasons for placing the first restoration on permanent tooth surfaces2275,810 patients; 9,902 dental restorations Reasons for replacement or repair of dental restorations2006,244 patients; 9,800 restorations CONDOR case-control study of osteonecrosis of the jaws37296 patients Retrospective cohort study of osteonecrosis of the jaws--572,606 patients Longitudinal study of dental restorations placed on previously un-restored surfaces 2075,332 patients; 9,270 dental restorations Longitudinal study of repaired or replaced dental restorations2005,800 patients; 9,800 restorations Development of a patient-based provider intervention for early caries management 10330 patients Patient satisfaction with dental restorations2004,640 patients Prevalence of questionable occlusal caries lesions962,552 caries lesions Longitudinal study of questionable occlusal caries lesions962,552 caries lesions Blood glucose testing in dental practice25375 patients Assessing the impact of participation in practice-based research on clinical practice and patient care 686-- Primary care management of TMJD disorders400+-- Totals3,15284,415 (excludes 1 study)