Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children Claudia Sengler, MDa, Andrea Heinzmann,

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Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children Claudia Sengler, MDa, Andrea Heinzmann, MDb, Silvija-Pera Jerkic, MDb, Assia Haider, BSa, Christine Sommerfeld, MSca, Bodo Niggemann, MDa, Susanne Lau, MDa, Johannes Forster, MDb, Antje Schuster, MDc, Wolfgang Kamin, MDd, Carl Bauer, MDe, Ingrid Laing, BScf, Peter LeSouef, MDf, Ulrich Wahn, MDa, Klaus Deichmann, MDb, Renate Nickel, MDa Journal of Allergy and Clinical Immunology Volume 111, Issue 3, Pages 515-519 (March 2003) DOI: 10.1067/mai.2003.180 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 CC16 genotyping by means of melting-curve analysis. A pair of fluorescence resonance energy transfer probes were applied to the PCR product and analyzed with the LightCycler system. A curve with one maximum represents a homozygous individual, peak temperature depending on sequence and fluorescence resonance energy transfer probes. A curve with 2 maxima characterizes a heterozygous subject. Journal of Allergy and Clinical Immunology 2003 111, 515-519DOI: (10.1067/mai.2003.180) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Median (with 25th-75th percentiles) PC20FEV1 values in asthmatic children with different CC16 genotypes at age 7 years. Lowest PC20FEV1 values were observed in individuals with the CC16*38AA genotype. All individuals homozygous for the *A allele were sensitized against at least one inhalant allergen. Journal of Allergy and Clinical Immunology 2003 111, 515-519DOI: (10.1067/mai.2003.180) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Exercise-induced decrease in FEV1 (median with 25th-75th percentile) was determined in 96 of 112 allergic asthmatic patients (Freiburg). Values are stratified for CC16*38AA , *38AG , and *38GG genotypes. Asthmatic children homozygous for the *38A allele showed a significantly greater decrease in FEV1 after exercise compared with individuals with the CC16*36AG or *36GG genotype. Journal of Allergy and Clinical Immunology 2003 111, 515-519DOI: (10.1067/mai.2003.180) Copyright © 2003 Mosby, Inc. Terms and Conditions